The Misidentification of Bacterial Genes as Human cDNAs: Was the Human D-1 Tumor Antigen Gene Acquired from Bacteria?

Skaar EP; Seifert HS

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The Misidentification of Bacterial Genes as Human cDNAs: Was the Human D-1 Tumor Antigen Gene Acquired from Bacteria?

机译：细菌基因误识别为人类cDNA：人类D-1肿瘤抗原基因是从细菌获得的吗？

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The initial analysis of the draft copy of the human genome sequence revealed the presence of several genes that were proposed to have been directly transferred from bacteria. We investigated the human D-1 antigen as a potential lateral transfer event. We report that although the human D-1 antigen seems to be an excellent candidate for lateral transfer, it is a contaminating bacterial sequence present in a human cDNA library that was included in the human genome analysis. Furthermore, several other genes present in the publicly available databases that were included in the analysis of the human genome are also likely contaminating bacterial sequences present in cDNA libraries. (c)2002 Elsevier Science (USA).

机译：对人类基因组序列草稿的初步分析显示，存在一些基因，这些基因被建议直接从细菌中转移过来。我们调查了人类D-1抗原作为潜在的横向转移事件。我们报告，虽然人类D-1抗原似乎是横向转移的极佳候选者，但它是存在于人类cDNA文库中的污染细菌序列，该序列已包含在人类基因组分析中。此外，人类基因组分析中所包括的公共数据库中存在的其他一些基因，也很可能污染了cDNA文库中存在的细菌序列。（c）2002 Elsevier Science（美国）。

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《Genomics》 |2002年第5期|共3页
作者
Skaar EP; Seifert HS;
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原文格式 PDF
正文语种 eng
中图分类遗传学;
关键词
Human; Antigens; Genome; Analysis of substances; 抗原; 基因组;

机译：Human;Antigens;Genome;Analysis of substances;抗原;基因组;

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1. The Misidentification of Bacterial Genes as Human cDNAs: Was the Human D-1 Tumor Antigen Gene Acquired from Bacteria? [J] . Skaar EP, Seifert HS Genomics . 2002,第5期

机译：细菌基因误识别为人类cDNA：人类D-1肿瘤抗原基因是从细菌获得的吗？
2. Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface [J] . Ribelles P., Benbouziane B., Langella P., Applied Microbiology and Biotechnology . 2013,第3期

机译：使用在其表面显示E7抗原的非转基因乳酸菌对小鼠乳头瘤病毒16型诱导的肿瘤的保护
3. A Vibrio harveyi insertional mutant in the cgtA (obg, yhbZ) gene, whose homologues are present in diverse organisms ranging from bacteria to humans and are essential genes in many bacterial species [J] . Agata Czy?, Ryszard Zielke, Gra?yna Konopa, Microbiology . 2001,第1期

机译：在CGTA（OBG，YHBZ）基因中的vibrio harveyi插入突变体，其同源物在不同的生物体中存在，从细菌到人类，并且是许多细菌种类中的必需基因
4. Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays [C] . Christine Sers, Oleg I. Tchernitsa, Johannes Zuber, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：基因表达在Ras癌基因转化的细胞系中和使用减法抑制杂交和cDNA阵列的固体瘤
5. Role of human carcinoembryonic antigen (CEA) in colorectal tumorigenesis: A tissue architecture model. [D] . Ilantzis, Christian. 1999

机译：人类癌胚抗原（CEA）在结直肠肿瘤发生中的作用：组织结构模型。
6. Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including ghosts nucleic acid-free bacterial rods. [O] . H I Huppertz, J Heesemann 1996

机译：人滑膜细胞的实验性耶尔森氏菌感染：活细菌的持续存在和细菌抗原沉积物的产生包括鬼魂无核酸的细菌棒。
7. Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including "ghosts," nucleic acid-free bacterial rods [O] . H I Huppertz, J Heesemann 1996

机译：实验性yersinia人类滑膜细胞的感染：活细菌持续性和细菌抗原沉积物，包括“鬼魂”的无核酸细菌棒
8. Selective Production of Human Antigen Specific Helper Factor from Normal Volunteers: Implications for Human Ir Genes [R] . Zvaifler, N. J., Feldmann, M., Howie, S., 1978

机译：从正常志愿者中选择性生产人类抗原特异性辅助因子：对人类Ir基因的影响

The Misidentification of Bacterial Genes as Human cDNAs: Was the Human D-1 Tumor Antigen Gene Acquired from Bacteria?

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