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Isochore structures in the mouse genome.

机译：小鼠基因组中的等时线结构。

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摘要

The distribution of the G+C content in the mouse genome has been studied using a windowless technique. We have found that: (i) Abrupt variations of the G+C content from a GC-rich region to a GC-poor region, and vice versa, occur frequently at some sites along the sequence of the mouse genome. (ii) Long domains with relatively homogeneous G+C content (isochores) exist, which usually have sharp boundaries. Consequently, 28 isochores longer than 1 Mb have been identified in the mouse genome. A homogeneity index was used to quantify the variations of the G+C content within isochores. The precise boundaries, sizes, and G+C contents of these isochores have been determined. The windowless technique for the G+C content computation was also used to analyze the DNA sequence containing the mouse MHC region, which has a GC-poor isochore. This isochore is located at the central part of the sequence with boundaries at 468,459 and 812,716 bp, where the sequence is extended from the centromeric end to the telomeric end. In addition, the analysis of a segment of the rat genome shows that the rat genome also has clear isochore structures.
机译：已经使用无窗技术研究了小鼠基因组中G + C含量的分布。我们发现：（i）G + C含量从富含GC的区域到缺乏GC的区域的突然变化，反之亦然，通常在小鼠基因组序列的某些位置发生。 （ii）存在具有相对均一的G + C含量（等位线）的长域，通常具有清晰的边界。因此，在小鼠基因组中已经鉴定出28个长于1 Mb的等时线。均质指数用于定量等时线内G + C含量的变化。已经确定了这些等时线的精确边界，大小和G + C含量。用于G + C含量计算的无窗口技术也用于分析含有小鼠MHC区的DNA序列，该区的GC等速线不足。该等轴线位于序列的中心部分，边界在468,459和812,716 bp处，其中该序列从着丝粒末端延伸至端粒末端。此外，对大鼠基因组片段的分析表明，大鼠基因组还具有清​​晰的等时线结构。

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