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首页> 外文期刊>Genomics >Combined-cross analysis of genome-wide linkage scans for experimental autoimmune encephalomyelitis in rat.
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Combined-cross analysis of genome-wide linkage scans for experimental autoimmune encephalomyelitis in rat.

机译：用于实验性自身免疫性脑脊髓炎的全基因组连锁扫描的组合交叉分析。

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Unbiased genetic analysis of experimental autoimmune encephalomyelitis (EAE) can provide insights into the pathogenesis of multiple sclerosis. To date five genome-wide scans using F2 crosses between different inbred rats have been performed with the aim of defining EAE-regulating quantitative trait loci (QTLs) as the starting point for identification of the underlying genes. We here report the first combined-cross analysis of three F2 crosses previously performed in our group. The majority of QTLs was shared between the different strain combinations and was therefore reproduced by the combined-cross analysis. Consequently, combined-cross analysis improved the power to detect QTLs with modest effects and narrowed QTL confidence intervals. The findings also demonstrate a lack of power in previous F2 crosses and encourage future use of larger populations. Moreover, the allelic states of shared QTLs could be established, thus providing critical information for narrowing QTLs and identifying the key polymorphism by subsequent haplotype analysis.
机译：实验性自身免疫性脑脊髓炎（EAE）的无偏遗传分析可以为多发性硬化症的发病机理提供见解。迄今为止，已经进行了五次使用不同近交大鼠之间的F2杂交的全基因组扫描，目的是将EAE调节定量性状基因座（QTL）定义为识别潜在基因的起点。我们在这里报告了先前在我们小组中进行的三个F2杂交的首次组合杂交分析。大多数QTL在不同菌株组合之间共享，因此通过交叉杂交分析得以复制。因此，组合交叉分析提高了检测具有适度效果并缩小QTL置信区间的QTL的能力。研究结果还表明，在以前的F2穿越中，力量不足，并鼓励将来使用更大的人群。此外，可以建立共享QTL的等位基因状态，从而为缩小QTL和通过随后的单倍型分析鉴定关键的多态性提供关键信息。

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