• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Alternative splicing and expression of human and mouse NFAT genes.
【24h】

Alternative splicing and expression of human and mouse NFAT genes.

机译：人和小鼠NFAT基因的可变剪接和表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Four members of the nuclear factor of activated T cells (NFAT) family (NFATC1, NFATC2, NFATC3, and NFATC4) are Ca(2+)-regulated transcription factors that regulate several processes in vertebrates, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Here we describe the structures and alternative splicing of the human and mouse NFAT genes, including novel splice variants for NFATC1, NFATC2, NFATC3, and NFATC4, and show the expression of different NFAT mRNAs in various mouse and human tissues and brain regions by RT-PCR. Our results show that alternatively spliced NFAT mRNAs are expressed differentially and could contribute to the diversity of functions of the NFAT proteins. Since NFAT family members are Ca(2+)-regulated and have critical roles in neuronal gene transcription in response to electrical activity, we describe the expression of NFATC1, NFATC2, NFATC3, and NFATC4 mRNAs in the adult mouse brain and in the adult human hippocampus using in situ hybridization and show that all NFAT mRNAs are expressed in the neurons of the mouse brain with specific patterns for each NFAT.
机译：活化T细胞（NFAT）家族的核因子（NFATC1，NFATC2，NFATC3和NFATC4）的四个成员是Ca（2+）调节的转录因子，可调节脊椎动物的几个过程，包括免疫系统的发育和功能，心血管，肌肉骨骼和神经系统。在这里，我们描述了人类和小鼠NFAT基因的结构和选择性剪接，包括NFATC1，NFATC2，NFATC3和NFATC4的新型剪接变体，并通过RT-显示了不同NFAT mRNA在各种小鼠和人类组织及大脑区域中的表达。 PCR。我们的结果表明，选择性剪接的NFAT mRNA表达差异，并且可能有助于NFAT蛋白的功能多样性。由于NFAT家族成员受到Ca（2+）调节并在神经元基因转录中具有关键作用，以响应电活动，我们描述了成年小鼠大脑和成年人类中NFATC1，NFATC2，NFATC3和NFATC4 mRNA的表达海马使用原位杂交技术，显示所有NFAT mRNA在小鼠脑神经元中均有表达，每种NFAT具有特定的模式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号