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首页> 外文期刊>Genomics >Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families.
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Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families.

机译：基于两个三代全兄弟杂种马参考家族的马单染色体遗传连锁图谱的单个连锁群。

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摘要

A genetic linkage map of the horse consisting of 742 markers, which comprises a single linkage group for each of the autosomes and the X chromosome, is presented. The map has been generated from two three-generation full-sibling reference families, sired by the same stallion, in which there are 61 individuals in the F2 generation. Each linkage group has been assigned to a chromosome and oriented with reference to markers mapped by fluorescence in situ hybridization. The average interval between markers is 3.7 cM and the linkage groups collectively span 2772 cM. The 742 markers comprise 734 microsatellite and 8 gene-based markers. The utility of the microsatellite markers for comparative mapping has been significantly enhanced by comparing their flanking sequences with the human genome sequence; this enabled conserved segments between human and horse to be identified. The new map provides a valuable resource for genetically mapping traits of interest in the horse.
机译：给出了由742个标记组成的马的遗传连锁图谱，其中包括每个常染色体和X染色体的单个连锁组。该图谱是由两个三代全兄弟参考系（由同一种公马选育）生成的，其中F2代有61个个体。每个连接基团已分配给一条染色体，并参照通过荧光原位杂交绘制的标记进行定位。标记之间的平均间隔为3.7 cM，连接基团的总跨度为2772 cM。 742个标记包括734个微卫星标记和8个基于基因的标记。通过将侧翼序列与人类基因组序列进行比较，微卫星标记用于比较作图的实用性得到了显着提高。这样可以识别人与马之间的保守区段。新的图谱提供了宝贵的资源，可用于对马的性状进行遗传定位。

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