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首页> 外文期刊>Genomics >Computational identification of potential transcriptional regulators of TGF-?1 in human atherosclerotic arteries
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Computational identification of potential transcriptional regulators of TGF-?1 in human atherosclerotic arteries

机译：人动脉粥样硬化动脉中TGF-β1潜在转录调节子的计算鉴定

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TGF-? is protective in atherosclerosis but deleterious in metastatic cancers. Our aim was to determine whether TGF-? transcriptional regulation is tissue-specific in early atherosclerosis. The computational methods included 5 steps: (i) from microarray data of human atherosclerotic carotid tissue, to identify the 10 best co-expressed genes with TGFB1 (TGFB1 gene cluster), (ii) to choose the 11 proximal promoters, (iii) to predict the TFBS shared by the promoters, (iv) to identify the common TFs co-expressed with the TGFB1 gene cluster, and (v) to compare the common TFs in the early lesions to those identified in advanced atherosclerotic lesions and in various cancers. Our results show that EGR1, SP1 and KLF6 could be responsible for TGFB1 basal expression, KLF6 appearing specific to atherosclerotic lesions. Among the TFs co-expressed with the gene cluster, transcriptional activators (SLC2A4RG, MAZ) and repressors (ZBTB7A, PATZ1, ZNF263) could be involved in the fine-tuning of TGFB1 expression in atherosclerosis.
机译：TGF-？在动脉粥样硬化中起保护作用，但对转移性癌症有害。我们的目的是确定是否TGF-？转录调节在早期动脉粥样硬化中是组织特异性的。计算方法包括5个步骤：（i）从人动脉粥样硬化颈动脉组织的微阵列数据中，鉴定与TGFB1（TGFB1基因簇）共同表达的10个最佳基因，（ii）选择11个近端启动子，（iii）预测启动子共有的TFBS，（iv）鉴定与TGFB1基因簇共表达的常见TF，（v）比较早期病变与晚期动脉粥样硬化病变和各种癌症中鉴定的TF。我们的结果表明，EGR1，SP1和KLF6可能是TGFB1基础表达的原因，KLF6似乎对动脉粥样硬化病变具有特异性。在与基因簇共表达的TF中，转录激活因子（SLC2A4RG，MAZ）和阻遏蛋白（ZBTB7A，PATZ1，ZNF263）可能参与动脉粥样硬化中TGFB1表达的微调。

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