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首页> 外文期刊>Genomics >Phylogenetic and syntenic analyses of the 12-spanner drug: H+ antiporter family 1 (DHA1) in pathogenic Candida species: Evolution of MDR1 and FLU1 genes
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Phylogenetic and syntenic analyses of the 12-spanner drug: H+ antiporter family 1 (DHA1) in pathogenic Candida species: Evolution of MDR1 and FLU1 genes

机译：系统发育和协同分析的12药：致病性念珠菌物种H +反转运蛋白家族1（DHA1）：MDR1和FLU1基因的进化

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摘要

Candida albicans and other pathogenic Candida species can develop resistance to clinical fungicides through active drug export mediated by multidrug efflux pumps, in particular by members of the drug:H+ antiporter family 1 (DHA1). The DHA1 proteins encoded in the genomes of 31 hemiascomycetous strains from 25 species were identified and homology relationships between these proteins and the functionally characterised DHA1 in the model yeast Saccharomyces cerevisiae were established. Gene neighbourhood analysis allowed the reconstruction of sixteen DHA1 lineages conserved during the CTG complex species evolution. The evolutionary history of C. albicans MDR1 and FLU1 genes and Candida dubliniensis, Candida tropicalis and Candida parapsilosis MDR1 genes was detailed. Candida genomes show an abundant number of MDR1 and FLU1 homologues but the chromosome environment where MDR1 homologues reside was poorly conserved during evolution. Gene duplication and loss are major mechanisms underlying the evolution of the DHA1 genes in Candida species.
机译：白色念珠菌和其他致病性念珠菌可通过多药外排泵，特别是H +反向转运蛋白家族1（DHA1）成员介导的活性药物输出，对临床杀菌剂产生抗药性。鉴定了来自25个物种的31株血丝囊菌菌株基因组中编码的DHA1蛋白，并建立了这些蛋白与啤酒酵母模型中功能鉴定的DHA1之间的同源性关系。基因邻域分析允许重建CTG复杂物种进化过程中保守的16个DHA1世系。详细介绍了白色念珠菌MDR1和FLU1基因以及假丝酵母，热带假丝酵母和副念珠菌MDR1基因的进化史。念珠菌基因组显示了大量MDR1和FLU1同源物，但MDR1同源物所在的染色体环境在进化过程中保守性很差。基因复制和丢失是念珠菌中DHA1基因进化的主要机制。

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