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首页> 外文期刊>Genomics >Remarkable synteny conservation of melanocortin receptors in chicken, human, and other vertebrates.
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Remarkable synteny conservation of melanocortin receptors in chicken, human, and other vertebrates.

机译：鸡，人和其他脊椎动物中黑皮质素受体的显着同构保守性。

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The melanocortin receptors (MCR) belong to the superfamily of G-protein-coupled receptors that participate in both peripheral and central functions, including regulation of energy balance. Genomic clones of the five chicken (GGA) MCRs were isolated and used to find the chromosomal location of each of the loci. The genes encoding MC2R and MC5R mapped to the middle part of the long arm of chromosome 2 (GGA2q22-q26) and MC4R proximally on the same chromosome arm, close to the centromere (2q12). This arrangement seems to be conserved on chromosome 18 in the human (HSA18). The MC1R and MC3R genes mapped to different microchromosomes that also appear to share homology with the respective human localization. The conserved synteny of the MC2R, MC5R, and MC4R cluster in chicken (GGA2), human (HSA18), and other mammals suggests that this cluster is ancient and was formed by local gene duplications that most likely occurred early in vertebrate evolution. Analysis of conserved synteny with mammalian genomes and paralogon segments prompted us to predict an ancestral gene organization that may explain how this family was formed through both local duplication and tetraploidization processes.
机译：黑皮质素受体（MCR）属于G蛋白偶联受体的超家族，参与周围和中央功能，包括调节能量平衡。分离了五个鸡（GGA）MCR的基因组克隆，并将其用于查找每个基因座的染色体位置。编码MC2R和MC5R的基因定位在2号染色体长臂的中间部分（GGA2q22-q26），而MC4R则位于同一染色体臂的近端，靠近着丝粒（2q12）。这种排列似乎在人的18号染色体上是保守的（HSA18）。 MC1R和MC3R基因定位于不同的微染色体，这些微染色体也似乎与各自的人类定位共享同源性。鸡（GGA2），人（HSA18）和其他哺乳动物中MC2R，MC5R和MC4R簇的保守同义表明，该簇很古老，由局部基因重复形成，很可能发生在脊椎动物进化的早期。保守基因与哺乳动物基因组和旁系同源基因片段的同源性分析促使我们预测了一个祖先的基因组织，这可能解释了这个家族如何通过局部复制和四倍体化过程而形成。

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