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首页> 外文期刊>Genomics >Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality.
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Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality.

机译：哺乳动物转录组的基因组组织：共调节和共功能。

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摘要

In studies of their transcriptional activity, genomes have shown a high order of organization. We assessed the question of how genomically neighboring genes are transcriptionally coupled across tissues and what could be the driving force behind their coupling. We focused our analysis on the transcriptome information for 13 tissues of Mus musculus and 79 tissues of Homo sapiens. The analysis of coexpression patterns of genomically adjacent genes across tissues revealed 2619 and 1275 clusters of highly coexpressed genes, respectively. Most of these clusters consist of pairs and triplets of genes. They span a limited genomic length and are phylogenetically conserved between human and mouse. These clusters consist mainly of nonparalogous genes and show a decreased functional and similar regulatory relationship to one another compared to general genomic neighbors. We hypothesize that these clusters trace back to large-scale, qualitative, persistent reorganizations of the transcriptome, while transcription factor regulation is likely to handle fine-tuning of transcription on shorter time scales. Our data point to so far uncharacterized cis-acting units and reject cofunctionality as a driving force.
机译：在研究其转录活性时，基因组显示出高度的组织性。我们评估了基因组上相邻基因在组织间如何转录偶联以及它们偶联背后的驱动力是什么的问题。我们将分析重点放在小家鼠的13个组织和智人的79个组织的转录组信息上。对整个组织中基因组邻近基因的共表达模式的分析分别揭示了2619和1275个高度共表达的基因簇。这些簇中的大多数由基因对和三联体组成。它们跨越有限的基因组长度，并且在人和小鼠之间在系统发育上是保守的。这些簇主要由非旁系基因组成，与普通的基因组邻居相比，彼此之间的功能和相似的调节关系降低。我们假设这些簇可以追溯到转录组的大规模，定性，持久性重组，而转录因子调控则可能在较短的时间尺度上处理转录的微调。我们的数据指向迄今未表征的顺式作用单元，并且拒绝将共功能性作为驱动力。

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