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首页> 外文期刊>Genomics >The role of climate in human mitochondrial DNA evolution: a reappraisal.
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The role of climate in human mitochondrial DNA evolution: a reappraisal.

机译：气候在人类线粒体DNA进化中的作用：重新评估。

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摘要

Previous studies have proposed that selection has been involved in the differentiation of human mitochondrial DNA (mtDNA) and climate was the main driving force. This viewpoint, however, gets no support from the subsequent studies and remains controversial thus far. To clarify this issue, a total of 237 complete mtDNA sequences belonging to autochthonous lineages from South Asia, Oceania, and East Asia were collected to seek for the imprint of selection. Based on nonsynonymous (N) and synonymous (S) substitutions analysis, our results confirmed that purifying selection was the predominant force during the evolution of human mtDNA. However, no significant and extensive difference was detected among these three regions, which did not support the climate adaptation hypothesis but preferred random genetic drift to be the main factor in shaping the current landscape of human mtDNA, at least those from Asian and Oceanian regions.
机译：先前的研究提出选择已参与人类线粒体DNA（mtDNA）的分化，而气候是主要驱动力。但是，这种观点并没有得到后续研究的支持，并且至今仍存在争议。为了澄清这个问题，总共收集了来自南亚，大洋洲和东亚的本地血统的237条完整mtDNA序列，以寻找选择的烙印。基于非同义（N）和同义（S）替代分析，我们的结果证实，纯化选择是人类mtDNA进化过程中的主要力量。但是，在这三个区域之间未发现任何重大而广泛的差异，这不支持气候适应假设，但更倾向于随机遗传漂移是塑造人类mtDNA当前格局的主要因素，至少是亚洲和大洋洲地区。

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