Genomic organization of the interleukin-1 locus.

Taylor SL; Renshaw BR; Garka KE; Smith DE; Sims JE

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Genomic organization of the interleukin-1 locus.

机译：IL-1基因座的基因组组织。

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Recent additions have expanded the interleukin (IL)-1 gene family to 10 members. We have determined the order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of these genes. The order and orientation of the mouse genes have been mapped, and the mouse locus compared with the human locus. There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7. (c)2002 Elsevier Science (USA).

机译：最近的补充已将白介素（IL）-1基因家族扩大到10个成员。我们已经确定了人类染色体2上的9个IL-1家族基因的顺序，方向和基因间隔。我们报道了其中三个基因的小鼠直系同源基因的cDNA序列。绘制了小鼠基因的顺序和方向，并与人类基因座进行了比较。与人类基因座相比，小鼠的基因座中有一个> 100 kb的断裂，位于Il1b和最靠近着丝粒的新型小鼠基因之间。小鼠似乎缺少人IL1F7的直系同源物。（c）2002 Elsevier Science（美国）。

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《Genomics》 |2002年第5期|共8页
作者
Taylor SL; Renshaw BR; Garka KE; Smith DE; Sims JE;
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正文语种 eng
中图分类遗传学;
关键词
Laboratory mice; Human; Interleukin-1; Environmental orientation; organizational; 白细胞介素1;

机译：Laboratory mice;Human;Interleukin-1;Environmental orientation;organizational;白细胞介素1;

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Genomic organization of the interleukin-1 locus.

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