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首页> 外文期刊>Genomics >A high-resolution comparative map between pig chromosome 17 and human chromosomes 4, 8, and 20: identification of synteny breakpoints.
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A high-resolution comparative map between pig chromosome 17 and human chromosomes 4, 8, and 20: identification of synteny breakpoints.

机译：猪第17号染色​​体与人第4号，8号和20号染色体之间的高分辨率比较图：同构断点的识别。

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We report on the construction of a high-resolution comparative map of porcine chromosome 17 (SSC17) focusing on evolutionary breakpoints with human chromosomes. The comparative map shows high homology with human chromosome 20 but suggests more limited homologies with other human chromosomes. SSC17 is of particular interest in studies of chromosomal organization due to the presence of QTLs that affect meat quality and carcass composition. A total of 158 pig ESTs available in databases or developed by the Sino-Danish Pig Genome Sequencing Consortium were mapped using the INRA-University of Minnesota porcine radiation hybrid panel. The high-resolution map was further anchored by fluorescence in situ hybridization. This study confirmed the extensive conservation between SSC17 and HSA20 and enabled the gene order to be determined. The homology of the SSC17 pericentromeric region was extended to other human chromosomes (HSA4, HSA8) and the chromosomal breakpoint boundaries were accurately defined. In total 15 breakpoints were identified.
机译：我们报告了重点放在与人类染色体进化断点的猪染色体17（SSC17）的高分辨率比较图的构建。比较图显示出与人类20号染色体的高度同源性，但暗示与其他人类染色体的同源性更有限。由于存在影响肉质和car体成分的QTL，SSC17在染色体组织研究中特别受关注。使用明尼苏达大学猪辐射混合杂交小组，对数据库中或由中丹猪基因组测序协会开发的总共158个猪EST进行了定位。高分辨率图通过荧光原位杂交进一步锚定。这项研究证实了SSC17和HSA20之间的广泛保守性，并使基因顺序得以确定。 SSC17着丝粒区域的同源性扩展到其他人类染色体（HSA4，HSA8），并且准确定义了染色体断点边界。总共确定了15个断点。

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