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首页> 外文期刊>Genomics >Over-represented localized sequence motifs in ribosomal protein gene promoters of basal metazoans.
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Over-represented localized sequence motifs in ribosomal protein gene promoters of basal metazoans.

机译：基底后生动物核糖体蛋白基因启动子中的过表达局部序列基序。

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摘要

Equimolecular presence of ribosomal proteins (RPs) in the cell is needed for ribosome assembly and is achieved by synchronized expression of ribosomal protein genes (RPGs) with promoters of similar strengths. Over-represented motifs of RPG promoter regions are identified as targets for specific transcription factors. Unlike RPs, those motifs are not conserved between mammals, drosophila, and yeast. We analyzed RPGs proximal promoter regions of three basal metazoans with sequenced genomes: sponge, cnidarian, and placozoan and found common features, such as 5'-terminal oligopyrimidine tracts and TATA-boxes. Furthermore, we identified over-represented motifs, some of which displayed the highest similarity to motifs abundant in human RPG promoters and not present in Drosophila or yeast. Our results indicate that humans over-represented motifs, as well as corresponding domains of transcription factors, were established very early in metazoan evolution. The fast evolving nature of RPGs regulatory network leads to formation of other, lineage specific, over-represented motifs.
机译：核糖体组装需要细胞中核糖体蛋白（RPs）的等分子存在，并且是通过核糖体蛋白基因（RPGs）与具有类似强度启动子的同步表达来实现的。 RPG启动子区域的过度代表的主题被确定为特定转录因子的目标。与RPs不同，哺乳动物，果蝇和酵母菌之间的那些基序不保守。我们分析了三个基本后生动物的RPGs近端启动子区域，它们具有测序的基因组：海绵，刺胞动物和placozoan，并发现了共同的特征，例如5'-末端寡嘧啶束和TATA-boxes。此外，我们鉴定了过度代表的基序，其中某些基序与人类RPG启动子中丰富的基序具有最高的相似性，而果蝇或酵母中则不存在。我们的结果表明，人类过度代表的基序以及转录因子的相应域在后生动物进化的早期就建立了。 RPG调节网络的快速发展性质导致形成其他特定于谱系的过高表达的基序。

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