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首页> 外文期刊>Genomics >Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus
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Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

机译：环境富集调节海马5-羟甲基胞嘧啶的动力学

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摘要

Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for similar to 40% of modified cytosine in the brain and has been implicated in DNA methylation-related plasticity. To identify the role of 5hmC in gene-environment interactions, we exposed both young (6-week-old) and aged (18-month-old) mice to both an enriched environment and a standard environment. Exposure to EE significantly improves learning and memory in aged mice and reduces 5hmC abundance in mouse hippocampus. Furthermore, we mapped the genome-wide distribution of 5hmC and found that the alteration of 5hmC modification occurred mainly at gene bodies. In particular, genes involved in axon guidance are enriched among the genes with altered 5hmC modification. These results together suggest that environmental enrichment could modulate the dynamics of 5hmC in hippocampus, which could potentially contribute to improved learning and memory in aged animals. (C) 2014 Elsevier Inc. All rights reserved.
机译：在表观遗传水平上介导的基因-环境相互作用可能为提供对环境变化的适当响应提供了第一步。 5-羟甲基胞嘧啶（5hmC）是一种由5-甲基胞嘧啶（5mC）衍生的DNA碱基，占大脑中修饰胞嘧啶的40％，与DNA甲基化相关的可塑性有关。为了确定5hmC在基因-环境相互作用中的作用，我们将年轻（6周龄）和年老（18个月大）小鼠都暴露于丰富的环境和标准环境中。暴露于EE可以显着改善老年小鼠的学习和记忆能力，并降低小鼠海马中5hmC的丰度。此外，我们绘制了5hmC的全基因组分布图，发现5hmC修饰的改变主要发生在基因体上。特别地，涉及轴突引导的基因在具有改变的5hmC修饰的基因中富集。这些结果共同表明，环境富集可以调节海马中5hmC的动力学，这可能有助于改善老年动物的学习和记忆能力。 （C）2014 Elsevier Inc.保留所有权利。

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