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Prevalence and mapping of a plasmid encoding a type IV secretion system in Acinetobacter baumannii

机译：鲍曼不动杆菌中编码IV型分泌系统的质粒的流行和作图

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摘要

We investigated the prevalence of a type IV secretion system (T4SS)-bearing plasmid among clinical isolates of carbapenem-resistant Acinetobacter baumannii (CRAB) using plasmid replicon typing. The complete sequence of a T4SS-bearing plasmid, pAB_CC, isolated from A. baumannii TYTH-1 was determined, and a comparative analysis of the T4SS gene modules was performed. Of the 129 isolates studied, GR6 (repAci6) was the most common (45 of 96 isolates) and was strongly linked with the T4SS. A comparative analysis of the T4SS locus in seven plasmid genomes, including pAB_CC, pACICU2, pABKp1, pABTJ1, p1BJAB0714, p2BJAB0868, and p2ABTCDC0715, indicated that fourteen genes on these plasmids were highly conserved compared to those of the F plasmid. Additionally, the chromosomes in the seven representative isolates may be evolutionarily distinct from their intrinsic T4SS-bearing plasmids, suggesting that the two T4SS lineages emerged long before the appearance of EC II. These two lineages are now widespread in A. baumannii strains. (C) 2014 Elsevier Inc. All rights reserved.
机译：我们使用质粒复制子分型法研究了耐碳青霉烯鲍曼不动杆菌（CRAB）的临床分离株中携带IV型分泌系统（T4SS）的质粒的患病率。确定了从鲍曼不动杆菌TYTH-1中分离的带有T4SS的质粒pAB_CC的完整序列，并对T4SS基因模块进行了比较分析。在研究的129个分离株中，GR6（repAci6）是最常见的（96个分离株中的45个），并且与T4SS紧密相关。对包括pAB_CC，pACICU2，pABKp1，pABTJ1，p1BJAB0714，p2BJAB0868和p2ABTCDC0715在内的七个质粒基因组中T4SS基因座的比较分析表明，与F质粒相比，这些质粒上的14个基因高度保守。另外，七个代表性分离物中的染色体可能在进化上不同于其固有的带有T4SS的质粒，这表明这两个T4SS谱系在EC II出现之前就已经出现了。这两个谱系现在在鲍曼不动杆菌菌株中很普遍。 （C）2014 Elsevier Inc.保留所有权利。

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