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首页> 外文期刊>Genomics >Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12.
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Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12.

机译：犬染色体12在与人类染色体6p12-q12相对应的区域中的物理和辐射杂交映射。

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摘要

The positional cloning of the hypocretin receptor 2, the gene for autosomal recessive canine narcolepsy, has led to the development of a physical map spanning a large portion of canine chromosome 12 (CFA12), in a region corresponding to human chromosome 6p12-q13. More than 40 expressed sequence tags (ESTs) were used in homology search experiments, together with chromosome walking, to build both physical and radiation hybrid maps of the CFA12 13-21 region. The resulting map of bacterial artificial chromosome ends, ESTs, and microsatellite markers represents the longest continuous high-density map of the dog genome reported to date. These data further establish the dog as a system for studying disease genes of interest to human populations and highlight feasible approaches for positional cloning of disease genes in organisms where genomic resources are limited. Copyright 2001 Academic Press.
机译：降钙素受体2（常染色体隐性犬性发作性睡病的基因）的位置克隆已导致在对应于人类染色体6p12-q13的区域中形成了跨越犬染色体12（CFA12）很大一部分的物理图谱。超过40个表达的序列标签（EST）用于同源搜索实验以及染色体行走，以构建CFA12 13-21区域的物理和辐射杂交图谱。细菌人工染色体末端，EST和微卫星标记的合成图代表了迄今为止报道的狗基因组最长的连续高密度图。这些数据进一步将狗确立为研究人群感兴趣的疾病基因的系统，并突出了在基因组资源有限的生物体中疾病基因位置克隆的可行方法。版权所有2001学术出版社。

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