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首页> 外文期刊>Genomics >Effects of chromosomal rearrangements on human-chimpanzee molecular evolution.
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Effects of chromosomal rearrangements on human-chimpanzee molecular evolution.

机译：染色体重排对人黑猩猩分子进化的影响。

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摘要

Many chromosomes are rearranged between humans and chimpanzees while others remain colinear. It was recently observed, based on over 100 genes, that the rates of protein evolution are substantially higher on rearranged than on colinear chromosomes during human-chimpanzee evolution. This finding led to the conclusion, since debated in the literature, that chromosomal rearrangements had played a key role in human-chimpanzee speciation. Here we re-examine this important conclusion by employing larger a data set (over 7000 genes), as well as alternative analyses. We show that the higher rates of protein evolution on rearranged chromosomes observed in the earlier study are not reproduced by our survey of the larger data set. We further show that the conclusion of the earlier study is likely confounded by two factors introduced by the relatively limited sample size: (1) nonuniform distribution of genes in the genome, and (2) stochastic noise in substitution rates inherent to short lineages such as the human-chimpanzee lineage. Our results offer a general cautionary note on the importance of controlling for hidden factors in studies involving bioinformatic surveys.
机译：许多染色体在人和黑猩猩之间重新排列，而其他则保持共线。最近观察到，基于100多个基因，在人类黑猩猩进化过程中，重排后的蛋白质进化速率大大高于共线染色体。从文献中进行辩论以来，这一发现得出结论，即染色体重排在人类黑猩猩物种形成中起着关键作用。在这里，我们通过使用更大的数据集（超过7000个基因）以及其他分析来重新检查这一重要结论。我们显示，在较早的研究中观察到的重排染色体上较高的蛋白质进化速率并未通过我们对较大数据集的调查得到再现。我们进一步表明，较早的研究结论可能与样本量相对有限所引入的两个因素混淆：（1）基因组中基因的不均匀分布;（2）短谱系固有的替代率中的随机噪声，例如黑猩猩的血统。我们的结果提供了一般性的注意事项，说明在涉及生物信息学调查的研究中控制隐藏因素的重要性。

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