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The genomics of gene expression.

机译：基因表达的基因组学。

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摘要

The study of gene regulation on a genomic scale has been constrained by the modest pace with which new trans-regulatory factors have been identified and by the fact that cis-regulatory sequences have to date been described even in part for only a small fraction of vertebrate genes. An indirect approach for assessing the significance of cis- and trans-regulatory mechanisms on a global scale is to utilize gene expression as a surrogate for transcriptional regulation and to combine genome-scale transcriptional profiling with studies of genetic variation, classical genetic techniques such as linkage analysis, and examination of allelic expression patterns that reveal cis-regulatory variability. A number of recent studies employing these methods provide insight into questions of central importance to our understanding of the larger role of transcriptional regulation in the organization of the human and other complex genomes.
机译：在基因组规模上进行基因调控的研究受到了新的反式调控因子鉴定的适度发展的限制，并且迄今为止迄今仅对一小部分脊椎动物描述了顺式调控序列这一事实基因。在全球范围内评估顺式和反式调控机制重要性的间接方法是利用基因表达作为转录调控的替代手段，并将基因组规模的转录谱与遗传变异研究，经典遗传技术（例如连锁）结合起来分析，并检查揭示了顺式调控变异性的等位基因表达模式。采用这些方法的许多最新研究为我们理解转录调控在人类和其他复杂基因组的组织中发挥更大作用的重要问题提供了见解。

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