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首页> 外文期刊>Genomics >Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.
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Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.

机译：精细的映射和全面的转录本分析揭示了大鼠10号染色体上新的1.17 Mb血压QTL区域内的非同义变体。

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摘要

The presence of blood pressure (BP) quantitative trait loci (QTL) on rat chromosome 10 has been clearly demonstrated by linkage analysis and substitution mapping. Using congenic strains containing the LEW rat chromosomal segments on the Dahl salt-sensitive (S) rat background, further iterations of congenic substrains were constructed and characterized to fine-map a chromosome 10 region (QTL1) linked to blood pressure. Comparison of seven congenic substrains refined QTL1 to a 1.17 Mb segment flanked by D10Mco88 and D10Mco89, which are located at 71,513,116 and 72,684,774 bp, respectively. The newly defined QTL1, containing 18 genes, is captured in its entirety within a single congenic substrain. A thorough transcript analysis revealed that 3 of these 18 genes, Ccl5, Ddx52, and RGD1559577, had nonsynonymous allelic variations between the S rat and the LEW rat. None of the detected transcripts within the newly defined QTL1 are implicated directly in BP control in humans or model organisms. Therefore, the present work defines a novel blood pressure QTL with three potential quantitative trait nucleotides.
机译：通过连锁分析和取代作图清楚地证明了大鼠10号染色体上的血压（BP）定量性状基因座（QTL）的存在。使用在Dahl盐敏感（S）大鼠背景上包含LEW大鼠染色体片段的同系菌株，构建了进一步的同系亚菌株迭代，并对其特征进行了精细映射，以绘制与血压相关的10号染色体区域（QTL1）。比较七个同系亚型精炼QTL1到一个D17Mco88和D10Mco89侧翼的1.17 Mb片段，它们分别位于71,513,116和72,684,774 bp。新定义的包含18个基因的QTL1被完整捕获在单个同基因亚菌株中。彻底的转​​录本分析显示，这18个基因中的3个（Ccl5，Ddx52和RGD1559577）在S大鼠和LEW大鼠之间具有非同义的等位基因变异。在新定义的QTL1中没有检测到的转录本直接与人类或模型生物的BP控制有关。因此，本工作定义了一种具有三个潜在的定量性状核苷酸的新型血压QTL。

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