• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Genome-wide dynamic changes of DNA methylation of repetitive elements in human embryonic stem cells and fetal fibroblasts
【24h】

Genome-wide dynamic changes of DNA methylation of repetitive elements in human embryonic stem cells and fetal fibroblasts

机译：人类胚胎干细胞和胎儿成纤维细胞中重复元件DNA甲基化的全基因组动态变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

DNA methylation changes in repetitive elements (REs) are associated with the regulation of gene transcription, embryonic development, differentiation and carcinogenesis. However, genome-wide analysis of DNA methylation of human REs is lacking. Here, we performed genome-wide methylation analysis of REs in nine repeat types in human embryonic stem cells (H1) and fetal fibroblasts (IMR90), and found that the potential for changes in the DNA methylation of REs was different among the nine repeat types and within different genomic regions. DNA methylation changes in the nine repeat types were related to the GC content and CpG density of the sequence contexts. The differentially methylated REs and targeted genes of different repeat types were associated with gene silencing in the transition from H1 to IMR90 cells. Our results suggest that a quarter of REs are involved in the reprogramming of DNA methylation which may play important epigenetic roles during cellular differentiation.
机译：重复元件（REs）中的DNA甲基化变化与基因转录，胚胎发育，分化和致癌作用的调节有关。然而，缺乏对人类RE的DNA甲基化的全基因组分析。在这里，我们对人类胚胎干细胞（H1）和胎儿成纤维细胞（IMR90）中9种重复类型的RE进行了全基因组甲基化分析，发现9种重复类型中RE的DNA甲基化变化的潜力不同在不同的基因组区域内。九种重复类型中的DNA甲基化变化与序列上下文中的GC含量和CpG密度有关。从H1到IMR90细胞的过渡过程中，差异甲基化的RE和不同重复类型的靶向基因与基因沉默相关。我们的结果表明，四分之一的RE参与DNA甲基化的重编程，这可能在细胞分化过程中起重要的表观遗传作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号