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首页> 外文期刊>Genomics >Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication.
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Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication.

机译：核激素受体基因NR1D2，THRB和RARB的链接：古代大规模复制的证据。

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摘要

The THRA gene encoding thyroid hormone receptor alpha shares an unusual partial overlap with the NR1D1 gene encoding the orphan receptor Rev-ErbAalpha. Though THRA and NR1D1 have close relatives in THRB and NR1D2, which encode TRbeta and Rev-ErbAbeta, these beta isoforms do not share an analogous overlap. Here we report that the human THRB and NR1D2 genes are separated by approximately 1 Mb on chromosome 3 and that these two genes are also linked to the RARB gene, which encodes retinoic acid receptor beta. Since previous results indicate that the THRA/NR1D1 locus is also linked to the RARA gene, these results suggest that the two receptor gene clusters were generated by a single large-scale duplication. Copyright 1999 Academic Press.
机译：编码甲状腺激素受体α的THRA基因与编码孤儿受体Rev-ErbAalpha的NR1D1基因有不寻常的部分重叠。尽管THRA和NR1D1在THRB和NR1D2中有近亲，它们编码TRbeta和Rev-ErbAbeta，但这些beta同工型没有相似的重叠。在这里，我们报告人类THRB和NR1D2基因在3号染色体上被大约1 Mb隔开，并且这两个基因也与RARB基因连锁，后者编码视黄酸受体β。由于先前的结果表明THRA / NR1D1基因座也与RARA基因相关，因此这些结果表明两个受体基因簇是通过一次大规模复制而产生的。版权所有1999 Academic Press。

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