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首页> 外文期刊>Genomics >Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7.
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Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7.

机译：Phemx是一种在造血细胞中表达的新型小鼠基因，可映射到远端7号染色体上的印迹簇。

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摘要

Phemx (Pan hematopoietic expression) is a novel murine gene expressed in developmentally regulated sites of hematopoiesis from early in embryogenesis through adulthood. Phemx is expressed in hematopoietic progenitors and mature cells of the three main hematopoietic lineages. Conceptual translation of the murine Phemx cDNA predicts a 25-kDa polypeptide with four hydrophobic regions and several potential phosphorylation sites, suggestive of a transmembrane protein involved in cell signaling. The PHEMX protein is structurally similar to tetraspanin CD81 (TAPA-1), a transmembrane protein involved in leukocyte activation, adhesion, and proliferation. Phemx maps to the distal region of chromosome 7, a segment of the mouse genome that contains a cluster of genes that exhibit genomic imprinting. However, imprinting analysis of Phemx at the whole organ level shows that it is biallelically expressed, suggesting that mechanisms leading to monoallelic expression are not imposed at this locus. The human PHEMX ortholog is specifically expressed in hematopoietic organs and tissues and, in contrast to murine Phemx, undergoes alternative splicing. The unique mode and range of Phemx expression suggest that it plays a role in hematopoietic cell function. Copyright 2000 Academic Press.
机译：Phemx（泛造血表达）是一种新的鼠类基因，从胚胎发生的早期一直到成年，都在造血作用的发育调控位点表达。 Phemx在三个主要造血谱系的造血祖细胞和成熟细胞中表达。鼠Phemx cDNA的概念翻译预测了一个25 kDa的多肽，具有四个疏水区域和几个潜在的磷酸化位点，提示跨膜蛋白参与细胞信号传导。 PHEMX蛋白在结构上与四跨膜蛋白CD81（TAPA-1）类似，后者是一种参与白细胞激活，粘附和增殖的跨膜蛋白。 Phemx映射到第7号染色体的远端区域，这是小鼠基因组的一部分，其中包含展示基因组印迹的基因簇。但是，在整个器官水平上对Phemx的印迹分析表明它是双等位表达的，这表明导致单等位基因表达的机制没有施加于该基因座。人PHEMX直系同源物在造血器官和组织中特异性表达，与鼠类Phemx相反，它经历了选择性剪接。 Phemx表达的独特模式和范围表明它在造血细胞功能中起作用。版权所有2000学术出版社。

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