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Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors.

机译:nope的克隆和表达,nope是与指导受体相关的免疫球蛋白超家族的新小鼠基因。

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摘要

The novel mouse gene Nope was identified due to its proximity to the Punc gene on chromosome 9. With a domain structure of four immunoglobulin domains, five fibronectin type III repeats, a single transmembrane domain, and a cytoplasmic domain, Nope encodes a new member of the immunoglobulin superfamily of cell surface proteins. It displays a high level of similarity to Punc, as well as to guidance receptors such as the Deleted in Colorectal Cancer protein and Neogenin. Nope is expressed during embryonic development in the notochord, in developing skeletal muscles, and later in the ventricular zone of the nervous system. In the adult brain, Nope can be detected in the hippocampus. Radiation hybrid mapping of Nope, Punc, and Neogenin placed all three genes in close vicinity on mouse chromosome 9. Copyright 2000 Academic Press.
机译:由于其与9号染色体上的Punc基因邻近,因此鉴定出了新的小鼠基因Nope。由于具有四个免疫球蛋白结构域,五个纤连蛋白III型重复序列,一个跨膜结构域和一个胞质结构域的结构域,Nope编码一个新成员细胞表面蛋白的免疫球蛋白超家族。它与Punc以及指导受体(如大肠癌中的Deleted蛋白和Neogenin)具有高度相似性。 Nope在脊索的脊柱发育,骨骼肌的发育以及神经系统的心室区的胚胎发育过程中表达。在成年大脑中,在海马体中未检测到Nope。 Nope,Punc和Neogenin的辐射杂交作图将所有三个基因都放置在小鼠9号染色体上。版权所有2000 Academic Press。

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