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首页> 外文期刊>Genomics >Specific interaction of PML bodies with the TP53 locus in Jurkat interphase nuclei.
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Specific interaction of PML bodies with the TP53 locus in Jurkat interphase nuclei.

机译：PML体与Jurkat相间核中TP53基因座的特异性相互作用。

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摘要

PML bodies play an important role in multiple pathways of growth control, such as transformation suppression, apoptosis, and Ras-induced senescence. However, the molecular and biological bases for these physiological phenomena are not well understood. The findings that viruses transcribe their genomes adjacent to PML bodies and that nascent RNA accumulates at their periphery have suggested that PML bodies are transcription-permissible domains. To investigate the role of PML bodies in regulation of cell transformation and apoptosis-related gene transcription, we employed the immuno-FISH method to examine the relationship between PML bodies and the TP53 and BCL2 gene loci. PML bodies were found to localize specifically with the TP53 locus in about 50% of Jurkat interphase nuclei, but never in proximity with the BCL2 locus. We speculate that PML bodies may interact directly with the TP53 DNA sequence to regulate TP53 gene expression.
机译：PML体在多种生长控制途径中发挥重要作用，例如转化抑制，细胞凋亡和Ras诱导的衰老。但是，对于这些生理现象的分子和生物学基础尚不十分了解。病毒在靠近PML体的地方转录其基因组，并在其周围积累新生的RNA的发现表明，PML体是转录允许的域。为了研究PML体在调节细胞转化和凋亡相关基因转录中的作用，我们采用免疫-FISH方法检查了PML体与TP53和BCL2基因位点之间的关系。发现PML体在约50％的Jurkat相间核中与TP53基因座特别相关，但从未与BCL2基因座接近。我们推测PML体可能直接与TP53 DNA序列相互作用以调节TP53基因表达。

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