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首页> 外文期刊>Genomics >Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.
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Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.

机译：新人类β-防御素基因的分布聚集在附睾功能不同部分的第20号染色体上。

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摘要

Human beta-defensins are a family of cationic peptides that share a pattern of six conserved cysteine residues. We describe the cloning and characterization of the cDNAs of five novel beta-defensin genes (DEFB25-DEFB29) clustered on chromosome 20p13, which were identified using a bioinformatics approach. Expression analysis revealed the occurrence of the transcripts in only a few organs, with the highest abundance in the male genital tract. Examination of beta-defensin expression in human epididymis by real-time quantitative RT-PCR revealed a distribution along the functionally different segments of the epididymal duct. In situ hybridization for one of the cDNAs shows mRNA restriction to the epithelial cell layer of the epididymis, known to secrete factors responsible for sperm maturation. We suggest that the novel peptides carry out physiological functions in the male genital tract that may not be directly related to bacterial growth inhibition in host defense.
机译：人β-防御素是一类阳离子肽，共有六个保守的半胱氨酸残基。我们描述了克隆和表征的五个新的β-防御素基因（DEFB25-DEFB29）聚集在20p13染色体上，这是使用生物信息学方法确定的。表达分析表明，转录本仅在少数器官中发生，其中男性生殖道中的丰度最高。通过实时定量RT-PCR检测人附睾中β-防御素的表达，发现沿附睾导管功能不同的部分分布。 cDNA之一的原位杂交显示，mRNA限制于附睾的上皮细胞层，已知分泌出负责精子成熟的因子。我们建议新型肽在男性生殖道中执行生理功能，这可能与宿主防御中的细菌生长抑制不直接相关。

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