• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >A 1-Mb bacterial clone contig spanning the endometrial cancer deletion region at 1p32-p33.
【24h】

A 1-Mb bacterial clone contig spanning the endometrial cancer deletion region at 1p32-p33.

机译：1-Mb细菌克隆重叠群，位于1p32-p33处的子宫内膜癌缺失区域。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our laboratory previously reported a high frequency of loss of heterozygosity (LOH) at 1p32-p33 in endometrial cancers. LOH at 1p32-p33 is a specific feature of one of the most aggressive forms of endometrial carcinoma, uterine papillary serous cancer (UPSC). The minimum region of allelic loss in UPSC is defined by D1S190 and D1S447, an interval corresponding to less than 1 cM. Here we describe the construction and characterization of a sequence-ready clone contig that spans the deletion region. The contig consists of 24 bacterial artificial chromosome clones and 18 P1 artificial chromosome clones and spans approximately 1050 kb. The consensus region of allelic loss between D1S190 and D1S447 represents approximately 792 kb. Eight previously described ESTs have been positioned within the contig. Copyright 1999 Academic Press.
机译：我们的实验室以前曾报道子宫内膜癌的1p32-p33杂合度（LOH）丢失频率很高。 1p32-p33处的LOH是子宫内膜癌最具侵袭性的形式之一，子宫乳头状浆液性癌（UPSC）的特定特征。 UPSC中等位基因缺失的最小区域由D1S190和D1S447定义，间隔对应于小于1 cM。在这里，我们描述了跨越缺失区域的序列就绪克隆重叠群的构建和表征。重叠群由24个细菌人工染色体克隆和18个P1人工染色体克隆组成，跨度约1050 kb。 D1S190和D1S447之间的等位基因缺失的共有区代表大约792 kb。已在重叠群中定位了八个先前描述的EST。版权所有1999 Academic Press。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号