Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13.

Claudio JO; Liew CC; Ma J; Heng HH; Stewart AK; Hawley RG

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Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13.

机译：一个新的WD重复基因WDR3的克隆和表达分析，映射到1p12-p13。

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WD repeat proteins are components of multiprotein complexes that are involved in a wide spectrum of cellular activities, such as cell cycle progression, signal transduction, apoptosis, and gene regulation. These proteins are characterized by repeat units bracketed by Gly-His and Trp-Asp (GH-WD). We report here the isolation of a new member of the WD repeat gene family, WDR3, which encodes a putative 943-amino-acid nuclear protein consisting of 10 WD repeat modules. WDR3 is widely expressed in hematopoietic cell lines and in nonhematopoietic tissues. Fluorescence in situ hybridization mapped WDR3 to human chromosome 1p12-p13, a region that is affected by chromosomal rearrangements in a number of hematologic malignancies and solid tumors. Copyright 1999 Academic Press.

机译：WD重复蛋白是多种蛋白复合物的组成部分，它们参与多种细胞活动，例如细胞周期进程，信号转导，细胞凋亡和基因调控。这些蛋白质的特征是由Gly-His和Trp-Asp（GH-WD）括起来的重复单元。我们在这里报告了WD重复基因家族的新成员WDR3的分离，该家族编码一个由10个WD重复模块组成的推定的943个氨基酸的核蛋白。 WDR3在造血细胞系和非造血组织中广泛表达。荧光原位杂交将WDR3定位到人类染色体1p12-p13，该区域受许多血液系统恶性肿瘤和实体瘤中染色体重排的影响。版权所有1999 Academic Press。

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《Genomics》 |1999年第1期|共5页
作者
Claudio JO; Liew CC; Ma J; Heng HH; Stewart AK; Hawley RG;
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正文语种 eng
中图分类遗传学;
关键词
Chromosomes; Human; Pair 1; Genes; Structural; Nuclear Proteins; Repetitive Sequences; Amino Acid; 染色体; 人; 1对; 基因; 结构; 核蛋白质类; 重复序列; 氨基酸;

机译：Chromosomes;Human;Pair 1;Genes;Structural;Nuclear Proteins;Repetitive Sequences;Amino Acid;染色体;人;1对;基因;结构;核蛋白质类;重复序列;氨基酸;

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1. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. [J] . Claudio JO, Liew CC, Ma J, Genomics . 1999,第1期

机译：一个新的WD重复基因WDR3的克隆和表达分析，映射到1p12-p13。
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6. Nuclear Factor-κB (NF-κB) Regulates the Expression of Human Testis-Enriched Leucine-Rich Repeats and WD Repeat Domain Containing 1 (LRWD1) Gene [O] . Yen-Ni Teng, Po-Jung Chuang, Yo-Wen Liu 2013

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机译：鉴定，克隆，表达和表征含有改变血小板反应蛋白重复域的诺氏疟原虫表面蛋白基因

Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13.

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