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首页> 外文期刊>Genomics >Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases.
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Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases.

机译：系统发育分析的真核RNA（cytosine-5）-甲基转移酶。

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摘要

RNA (cytosine-5)-methyltransferases (RCMTs) have been characterized both in prokaryotic and eukaryotic organisms. The RCMT family, however, remains largely uncharacterized, as opposed to the family of DNA (cytosine-5)-methyltransferases which has been studied in depth. In the present study, an in silico identification of the putative 5-methylcytosine RNA-generating enzymes in the eukaryotic genomes was performed. A comprehensive phylogenetic analysis of the putative eukaryotic RCMT-related proteins has been performed in order to redefine subfamilies within the RCMT family. Five distinct eukaryotic subfamilies were identified, including the three already known (NOP2, NCL1 and YNL022c), one novel subfamily (RCMT9) and a fifth one which hitherto was considered to exist exclusively in prokaryotes (Fmu). The potential evolutionary relationships among the different eukaryotic RCMT subfamilies were also investigated. Furthermore, the results of this study add further support to a previous hypothesis that RCMTs represent evolutionary intermediates of RNA (uridine-5)-methyltransferases and DNA (cytosine-5)-methyltransferases.
机译：RNA（cytosine-5）-methyltransferases（RCMTs）已经在原核和真核生物中得到了表征。然而，与已经深入研究的DNA（胞嘧啶5）-甲基转移酶家族相反，RCMT家族仍然基本上没有特征。在本研究中，对真核生物基因组中推定的5-甲基胞嘧啶RNA产生酶进行了计算机鉴定。为了重新定义RCMT家族中的亚家族，已经对假定的真核RCMT相关蛋白进行了全面的系统发育分析。确定了五个不同的真核亚家族，包括三个已知的（NOP2，NCL1和YNL022c），一个新的亚家族（RCMT9）和第五个迄今为止被认为仅存在于原核生物（Fmu）中的亚家族。还研究了不同真核RCMT亚家族之间潜在的进化关系。此外，这项研究的结果进一步支持了先前的假设，即RCMT代表RNA（尿苷5）-甲基转移酶和DNA（胞嘧啶5）-甲基转移酶的进化中间体。

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