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Identification of small non-coding RNAs in the planarian Dugesia japonica via deep sequencing

机译：通过深度测序鉴定大叶紫D中的小非编码RNA

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Freshwater planarian flatworm possesses an extraordinary ability to regenerate lost body parts after amputation; it is perfect organism model in regeneration and stem cell biology. Recently, small RNAs have been an increasing concern and studied in many aspects, including regeneration and stem cell biology, among others. In the current study, the large-scale cloning and sequencing of sRNAs from the intact and regenerative planarian . Dugesia japonica are reported. Sequence analysis shows that sRNAs between 18nt and 40nt are mainly microRNAs and piRNAs. In addition, 209 conserved miRNAs and 12 novel miRNAs are identified. Especially, a better screening target method, negative-correlation relationship of miRNAs and mRNA, is adopted to improve target prediction accuracy. Similar to miRNAs, a diverse population of piRNAs and changes in the two samples are also listed. The present study is the first to report on the important role of sRNAs during planarian . Dugesia japonica regeneration.
机译：截肢后，淡水planar涡虫具有非凡的能力来再生失去的身体部位。它是再生和干细胞生物学的理想生物模型。近年来，小RNA越来越引起人们的关注，并在许多方面进行了研究，包括再生和干细胞生物学等。在当前的研究中，从完整的和再生的涡虫中大规模克隆和测序sRNA。据报道有日本uge。序列分析表明，介于18nt和40nt之间的sRNA主要是microRNA和piRNA。另外，鉴定出209个保守的miRNA和12个新颖的miRNA。特别地，采用更好的筛选目标方法，即miRNA和mRNA的负相关关系，以提高目标预测的准确性。与miRNA相似，也列出了piRNA的不同群体，并列出了两个样品的变化。本研究是第一次报告sRNA在涡虫中的重要作用。矮牵牛再生。

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