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首页> 外文期刊>Gait & posture >Levodopa effect on electromyographic activation patterns of tibialis anterior muscle during walking in Parkinson's disease.
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Levodopa effect on electromyographic activation patterns of tibialis anterior muscle during walking in Parkinson's disease.

机译：左旋多巴对帕金森病行走过程中胫骨前肌的肌电图激活模式的影响。

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Previous studies have reported that patients with Parkinson's disease (PD) show, in the "off medication" state, a reduced activation of tibialis anterior (TA) in the late swing-early stance phase of the gait cycle. In PD patients the pathophysiological picture may cause differences among the stride cycles. Our aims were to evaluate how frequently TA activity is reduced in the late swing-early stance phase and if there is a relationship between the TA pattern and the clinical picture. Thirty PD patients were studied 2 h after Levodopa administration ("on-med") and 12 h after Levodopa wash-out ("off-med"). They were evaluated by the Unified Parkinson's Disease Rating Scale (UPDRS III) and surface electromyography of TA and gastrocnemius medialis (GM). The root mean square (RMS) of the TA activity in late swing-early stance phase (RMS-A) was normalized as a percent of the RMS of the TA activity in late stance-early swing (RMS-B). RMS-A was reduced in 30% of patients in the "off-med" condition. Within these patients, the percentage of stride cycles with reduced RMS-A, ranged between 28% and 83%. After Levodopa intake, no stride cycle showed reduced RMS-A. Patients with reduced RMS-A had a lower UPDRS III total score in the "on-med" rather than in the "off-med" condition (p=0.02). Our data confirm and extend previous observations indicating that, in "off-med" the function of TA is impaired in those patients clinically more responsive to Levodopa. TA activation is reduced in a relatively high percent of gait cycles in the "off-med" state. Since the variability of TA activation disappears after Levodopa administration, this phenomenon could be the expression of an abnormal dopaminergic drive.
机译：先前的研究报道，患有帕金森氏病（PD）的患者显示，在“停药”状态下，步态周期的后期摆动早期阶段的胫骨前（TA）激活减少。在PD患者中，病理生理特征可能导致跨步周期之间的差异。我们的目的是评估在秋千早期阶段多长时间减少一次TA活性，以及​​TA模式和临床表现之间是否存在关系。服用左旋多巴后2小时（“就医”）和左旋多巴冲洗后12小时（“就医”）对30名PD患者进行了研究。用统一帕金森氏病评分量表（UPDRS III）和TA和腓肠肌内侧表面肌电图（GM）进行评估。将后期摆动早期姿态阶段（RMS-A）中TA活性的均方根（RMS）标准化为后期摆动早期姿态（RMS-B）中TA活动的RMS的百分比。在“非医疗”条件下，有30％的患者的RMS-A降低。在这些患者中，RMS-A降低的步幅百分比在28％至83％之间。左旋多巴摄入后，没有步幅显示RMS-A降低。 RMS-A降低的患者在“就医”状态而非“就医”条件下的UPDRS III总评分较低（p = 0.02）。我们的数据证实并扩展了先前的观察结果，表明在“非医学”阶段，TA的功能在临床上对左旋多巴有更高反应的那些患者中受损。在“离场”状态下，步态周期中相对较高的步伐可以减少TA的激活。由于左旋多巴给药后TA激活的变异性消失，这种现象可能是异常多巴胺能驱动的表达。

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