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首页> 外文期刊>Genomics >Purifying selection against gene conversions in the folate receptor genes of primates.
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Purifying selection against gene conversions in the folate receptor genes of primates.

机译：纯化针对灵长类动物叶酸受体基因中的基因转化的选择。

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摘要

We characterized the gene conversions between the human folate receptor (FOLR) genes and those of five other primate species. We found 26 gene conversions having an average length of 534 nucleotides. The length of these conversions is correlated with sequence similarity, converted regions have a higher GC-content and the average size of converted regions from a functional donor to another functional donor is significantly smaller than the average size from a functional donor to a pseudogene. Furthermore, the few conversions observed in the FOLR1 and FOLR2 genes did not change any amino acids in their coding regions and did not affect their promoter regions. In contrast, the promoter and coding regions of the FOLR3 gene are frequently converted and these conversions changed many amino acids in marmoset. These results suggest that purifying selection is limiting the functional impact that frequent gene conversions have on functional folate receptor genes.
机译：我们表征了人类叶酸受体（FOLR）基因和其他五个灵长类物种之间的基因转换。我们发现26个基因转化的平均长度为534个核苷酸。这些转化的长度与序列相似性相关，转化的区域具有较高的GC含量，并且从功能性供体到另一种功能性供体的转化区域的平均大小显着小于从功能性供体到假基因的平均大小。此外，在FOLR1和FOLR2基因中观察到的很少的转化不会改变其编码区中的任何氨基酸，也不会影响其启动子区。相反，FOLR3基因的启动子和编码区经常被转换，这些转换改变了mar猴中的许多氨基酸。这些结果表明纯化选择限制了频繁的基因转化对功能性叶酸受体基因的功能影响。

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