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Comparative mapping of the human homologue of the rat diabetes susceptibility gene lyp to a 1.3-Mb segment on HSA7.

机译:大鼠糖尿病易感基因lyp的人类同源物与HSA7上的1.3 Mb片段的比较作图。

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摘要

The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved segment: CASP2 and PRSS1 are localized to 7q35, while NPY is localized to 7p15.1. This raises the question whether the human homologue of Lyp is linked to CASP2/PRSS1 or to NPY. We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35. Copyright 2000 Academic Press.
机译:大鼠糖尿病易感基因Lyp或淋巴细胞减少症已定位于RNO4。与Lyp最接近的是caspase-2(Casp2)和胰胰蛋白酶1(Prss1)基因,而神经肽Y(Npy)是最接近远端的基因。在人类中,这三个基因在HSA7上是同系的,但它们不在保守区段上:CASP2和PRSS1定位于7q35,而NPY定位于7p15.1。这就提出了一个问题:Lyp的人类同源物是与CASP2 / PRSS1还是与NPY相关。我们提出了大鼠和人类的Lyp区的比较图,将基因分配给Rny3和ABP1之间在7q35的1.3-Mb区段。版权所有2000学术出版社。

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