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Proposed standard nomenclature for the alpha- and beta-globin gene families

机译:拟议的α-和β-珠蛋白基因家族的标准命名法

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摘要

The globin family of genes and proteins has been a recurrent object of study for many decades. This interest has generated a vast amount of knowledge. However it has also created an inconsistent and confusing nomenclature, due to the lack of a systematic approach to naming genes and failure to reflect the phylogenetic relationships among genes of the gene family. To alleviate the problems with the existing system, here we propose a standardized nomenclature for the alpha and beta globin family of genes, based on a phylogenetic analysis of vertebrate alpha and beta globins, and following the Guidelines for Human Gene Nomenclature.
机译:数十年来,基因和蛋白质的球蛋白家族一直是研究的一个经常性对象。这种兴趣产生了大量的知识。但是,由于缺乏一种系统的基因命名方法并且未能反映基因家族基因之间的系统发育关系,因此它也产生了一个前后不一致的术语。为了缓解现有系统的问题,在此,我们根据脊椎动物α和β球蛋白的系统发育分析并遵循人类基因命名准则,为α和β球蛋白家族基因提出了一个标准化的命名法。

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