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首页> 外文期刊>Genes & Genetic Systems >On the origin and function of an insertion element VPaI-1 specific to post-1995 pandemic Vibrio parahaemolyticus strains.
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On the origin and function of an insertion element VPaI-1 specific to post-1995 pandemic Vibrio parahaemolyticus strains.

机译：关于1995年后大流行性副溶血弧菌菌株特有的插入元件VPaI-1的起源和功能。

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摘要

Since 1995, new virulent strains of Vibrio parahaemolyticus have emerged and spread throughout the world. These "pandemic" strains have four strain specific genomic islands (GIs), which are considered to be potential factors of the pandemicity. We investigated the origin and function of 24 genes in the so-called VPaI-1, one of the four GIs, by searching homologs in various species in Bacteria and Archaea. Of these 24 genes, two are found only in Vibrio vulnificus CMCP6 and Shewanella sp. MR-7. The genomic segment (- 8 kb) encompassing the two genes shows the synteny among the three species. Since many of the Shewanella species can grow at 4 degrees C, these two genes may be candidates of adaptation to temperature stress. Further, we found a candidate for a swarming gene, which is reported as the V. cholerae virulence gene. Based on these findings, we hypothesized the emergence of pandemicity and discuss the mechanism for how these strains spread throughout the world.
机译：自1995年以来，出现了新的副溶血性弧菌毒株，并在全世界传播。这些“大流行”菌株具有四个菌株特异性基因组岛（GIs），它们被认为是大流行的潜在因素。我们通过搜索细菌和古细菌中各种物种的同源物，研究了所谓的VGI-1的VPaI-1中24个基因的起源和功能。在这24个基因中，两个仅在创伤弧菌CMCP6和希瓦氏菌中发现。 MR-7。包含两个基因的基因组片段（约8 kb）显示了这三个物种之间的同构关系。由于许多希瓦氏菌物种可以在4摄氏度下生长，因此这两个基因可能是适应温度胁迫的候选基因。此外，我们发现了一个蜂群基因的候选基因，据报道它是霍乱弧菌的毒力基因。基于这些发现，我们假设了流行病的出现，并讨论了这些菌株如何在世界范围内传播的机制。

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