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Transcription factors of M-phase cyclin CLB2 in the yeast cell wall integrity checkpoint

机译：酵母细胞壁完整性检查点中M期细胞周期蛋白CLB2的转录因子

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摘要

The cell wall integrity checkpoint coordinates cell wall synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae. It has been reported that this checkpoint arrests the cell cycle at G2/M phase with repression of the M phase cyclin Clb2p at the transcriptional level, under perturbation of cell wall synthesis. We demonstrate that an override of this checkpoint with accumulation of CLB2 mRNA is induced when negative CLB2 transcription factors are deleted or when positive CLB2 transcription factors are overproduced in cell wall-defective cells. Our data imply that transcription factors for CLB2 are involved in the cell wall integrity checkpoint system and suggest that there are multiple regulation pathways of the checkpoint.
机译：细胞壁完整性检查点可协调发芽酵母酿酒酵母中的细胞壁合成和有丝分裂。据报道，在细胞壁合成受到干扰的情况下，该检查点在转录水平上抑制了M期细胞周期蛋白Clb2p，从而使G2 / M期细胞周期停滞。我们证明，当删除负CLB2转录因子或在细胞壁缺陷细胞中过度产生正CLB2转录因子时，会诱导该检查点与CLB2 mRNA的积累重叠。我们的数据表明，CLB2的转录因子参与了细胞壁完整性检查点系统，并表明该检查点有多种调节途径。

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