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首页> 外文期刊>Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses >Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila.
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Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila.

机译：非典型肌球蛋白Dachs的平面极化定向果蝇中的细胞分裂。

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摘要

Tissues can grow in a particular direction by controlling the orientation of cell divisions. This phenomenon is evident in the developing Drosophila wing epithelium, where the tissue becomes elongated along the proximal-distal axis. We show that orientation of cell divisions in the wing requires planar polarization of an atypical myosin, Dachs. Our evidence suggests that Dachs constricts cell-cell junctions to alter the geometry of cell shapes at the apical surface, and that cell shape then determines the orientation of the mitotic spindle. Using a computational model of a growing epithelium, we show that polarized cell tension is sufficient to orient cell shapes, cell divisions, and tissue growth. Planar polarization of Dachs is ultimately oriented by long-range gradients emanating from compartment boundaries, and is therefore a mechanism linking these gradients with the control of tissue shape.
机译：通过控制细胞分裂的方向，组织可以沿特定方向生长。这种现象在正在发展的果蝇翅上皮中很明显，那里的组织沿近端-远端轴拉长。我们表明，机翼中细胞分裂的方向需要非典型肌球蛋白Dachs的平面极化。我们的证据表明，Dachs收缩细胞-细胞连接以改变顶表面的细胞形状的几何形状，然后细胞形状决定了有丝分裂纺锤体的方向。使用生长的上皮细胞的计算模型，我们显示极化的细胞张力足以定向细胞形状，细胞分裂和组织生长。 Dachs的平面极化最终由来自隔室边界的远程梯度定向，因此是一种将这些梯度与组织形状控制联系在一起的机制。

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