Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.

Kosoy R; Concannon P

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Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.

机译：SUMO4，TAB2和NFkappaB中的功能变异以及1型糖尿病的风险。

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Several functional genetic variants that can potentially modulate the activity of NFkappaB have been recently described. As reduced NFkappaB activity has been implicated in risk for autoimmune diabetes in the NOD mouse, these variants were tested for allelic association with type 1 diabetes (T1D) in a family based study. Alleles at markers in the TAB2/SUMO4 locus on chromosome 6q had been previously reported to be associated with T1D in two separate studies, but these studies disagreed on the identity of the risk allele. The current study failed to confirm either of these results. No significant evidence of association with T1D was obtained for three SNP markers in the TAB2/SUMO4 region. An additional functional variant in the promoter of the NFKB1 gene that has been shown to directly affect the expression of NFkappaB was also tested.

机译：最近已经描述了几种可以潜在地调节NFkappaB活性的功能遗传变异。由于降低的NFkappaB活性与NOD小鼠自身免疫性糖尿病的风险有关，因此在一项基于家庭的研究中测试了这些变体与1型糖尿病（T1D）的等位基因关联。先前在两项单独的研究中已报道了染色体6q上TAB2 / SUMO4基因座上标记的等位基因与T1D相关，但这些研究在风险等位基因的身份上存在分歧。当前的研究未能证实这些结果。对于TAB2 / SUMO4区域中的三个SNP标记，没有获得与T1D相关的明显证据。还测试了已证明直接影响NFkappaB表达的NFKB1基因启动子中的其他功能性变体。

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《Genes and immunity.》 |2005年第3期|共5页
作者
Kosoy R; Concannon P;
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正文语种 eng
中图分类医学遗传学;
关键词
Adaptor Proteins; Signal Transducing; Diabetes Mellitus; Type 1; Genetic Predisposition to Disease; 疾病遗传易感性; NF-κB;

机译：Adaptor Proteins;Signal Transducing;Diabetes Mellitus;Type 1;Genetic Predisposition to Disease;疾病遗传易感性;NF-κB;

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1. Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes. [J] . Kosoy R, Concannon P Genes and immunity. . 2005,第3期

机译：SUMO4，TAB2和NFkappaB中的功能变异以及1型糖尿病的风险。
2. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes [J] . Guo DH, Li MY, Zhang Y, Nature Genetics . 2004,第8期

机译：SUMO4的功能性变异体，一种新的IκB alpha修饰剂，与1型糖尿病有关
3. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. [J] . Bottini N, Musumeci L, Alonso A, Nature Genetics . 2004,第4期

机译：淋巴样酪氨酸磷酸酶的功能性变异与I型糖尿病有关。
4. A Bayesian Network analysis of the probabilistic relations between risk factors in the predisposition to type 2 diabetes. [C] . Francesco Sambo, Barbara Di Camillo, Alberto Franzin, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：2型糖尿病患者风险因素与2型糖尿病患者概率关系的贝叶斯网络分析。
5. Towards creating type 2 diabetes mass mediated health communication strategies: An examination of Latino and non -Latino White college students' perception of the risk of developing type 2 diabetes. [D] . Reyes Velazquez, Wanda. 2005

机译：建立2型糖尿病的大众传播健康交流策略的方法：检查拉丁裔和非拉丁裔白人大学生对2型糖尿病风险的认识。
6. Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population [O] . Laeya Abdoli Najmi, Ingvild Aukrust, Jason Flannick, 2017

机译：HNF1A的功能研究确定罕见变异是普通人群中2型糖尿病的危险因素
7. Corrigendum: A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes [O] . D Guo, M Li, Y Zhang, 2004

机译：勘误：Sumo4的功能变体，一种新的IκBα改性剂，与1型糖尿病有关

Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.

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