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首页> 外文期刊>Biogerontology >Circadian rhythms of body temperature and locomotor activity in aging BALB/c mice: early and late life span predictors
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Circadian rhythms of body temperature and locomotor activity in aging BALB/c mice: early and late life span predictors

机译：衰老的BALB / c小鼠体温和运动活动的昼夜节律：早期和晚期寿命预测因子

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摘要

Impairment of one or more parameters of circadian rhythms (CR) of body temperature (BT) and locomotor activity (LMA) are considered among the hallmarks of mammalian aging. These alterations are frequently used as markers for imminent death in laboratory mice. However, there are still contradictory data for particular strains and it is also uncertain which changes might predict senescence changes later in life, including the force of mortality. In the present paper we use telemetry to study LMA and CR of BT during aging of BALB/c mice. At our knowledge this is the first time that CR of BT and LMA are investigated in this strain in a range of age covering the whole lifespan, from young adult up to very old age. CR of BT was analyzed with a cosine model using a cross sectional approach and follow-up measurements. The results show that BT, LMA, amplitude, goodness-of-fit (GoF) to circadian cycle of temperature decrease with different shapes during chronological age. Moreover, we found that the % change of amplitude and BT in early life (5-19 months) can predict the remaining lifespan of the mice. Later in life (22-32 months), best predictors are single measurements of LMA and GoF. The results of this study also offer potential measures to rapidly identifying freely unrestrained mice with the worst longitudinal outcome and against which existing or novel biomarkers and treatments may be assessed.
机译：体温（BT）和运动活动（LMA）的昼夜节律（CR）的一个或多个参数受损被认为是哺乳动物衰老的标志。这些改变常被用作实验室小鼠即将死亡的标记。但是，对于特定的菌株，仍然有矛盾的数据，也不确定哪些变化可以预测生命后期的衰老变化，包括死亡率。在本文中，我们使用遥测技术研究BALB / c小鼠衰老过程中BT的LMA和CR。据我们所知，这是首次在该菌株的整个年龄范围内研究BT和LMA的CR，从年轻人到高龄。使用余弦模型使用横截面方法和后续测量分析BT的CR。结果表明，随着时间的推移，不同形状的BT，LMA，幅度，拟合优度（GoF）对温度的昼夜节律周期呈下降趋势。此外，我们发现早期（5-19个月）振幅和BT的变化百分比可以预测小鼠的剩余寿命。在生命的后期（22-32个月），最好的预测指标是对LMA和GoF的单次测量。这项研究的结果还提供了可能的措施，以快速识别出纵向结果最差的自由，不受约束的小鼠，并据此对现有或新颖的生物标志物和治疗方法进行评估。

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