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首页> 外文期刊>Bioinspiration & biomimetics >Coaxially electrospun microanofibrous poly(epsilon-caprolactone)/eggshell-protein scaffold
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Coaxially electrospun microanofibrous poly(epsilon-caprolactone)/eggshell-protein scaffold

机译：同轴电纺微/纳米纤维聚（ε-己内酯）/卵壳蛋白支架

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摘要

Eggshell membrane (ESM) has potential as a natural scaffold because of its highly porous structure and good biocompatibility. To mimic its structure and surface properties, soluble eggshell membrane protein (SEP) was extracted from ESM and electrospun with a biodegradable polymer, poly(epsilon-caprolactone) (PCL). SEP/PCL microanofibers were fabricated using a coaxial electrospinning process with a dual nozzle and an auxiliary cylindrical electrode. The fiber web was characterized using the water contact angle, pore-size distribution, mechanical properties and cellular behavior. The SEP/PCL web, which demonstrated the feasibility of producing a scaffold with adequate hydrophilicity, suitable pore size and good mechanical properties compared to a pure PCL microanofiber web, exhibits the ability to mimic a natural biomaterial.
机译：蛋壳膜（ESM）由于其高度多孔的结构和良好的生物相容性而具有作为天然支架的潜力。为了模拟其结构和表面特性，从ESM中提取了可溶性蛋壳膜蛋白（SEP），并使用可生物降解的聚合物聚（ε-己内酯）（PCL）进行了静电纺丝。 SEP / PCL微纤维/纳米纤维使用同轴电纺丝工艺制造，带有双喷嘴和辅助圆柱形电极。使用水接触角，孔径分布，机械性能和多孔性能来表征纤维网。与纯PCL微米/纳米纤维网相比，SEP / PCL网证明了生产具有足够亲水性，合适孔径和良好机械性能的支架的可行性，它具有模仿天然生物材料的能力。

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