Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits

A.H. Souza; C.A.A. Valadao; M.A. SelegattoR.M. AlmeidaM. Macari

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Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits

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The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5 mug.kg(-1) body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onsetand magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO mayprovide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kappa B mediated events, such as fever.

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《Arquivo Brasileiro de Medicina Veterinaria e Zootecnia》 |2008年第3期|626-630|共5页
作者
A.H. Souza; C.A.A. Valadao; M.A. SelegattoR.M. AlmeidaM. Macari;
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作者单位

Faculdade de Ciências Agrárias e Veterinárias - UNESP Via de acesso Prof. Paulo Donato Castellane, s/n 14884-900 - Jaboticabal, SP;

Faculdade de Ciências Agrárias e Veterinárias - UNESP Via de acesso Prof. Paulo Donato Castellane, s/n 14884-900- Jaboticabal, SP;

Departamento de Medicina Veterinária - UPIS - Brasília, DF;

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原文格式 PDF
正文语种英语
中图分类动物医学（兽医学）;
关键词
LPS; febre; DMSO; coelhos; fever; rabbits;

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Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits

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