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首页> 外文期刊>British Journal of Clinical Pharmacology >Indirect comparison analysis of efficacy and safety between olanzapine and aripiprazole for schizophrenia
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Indirect comparison analysis of efficacy and safety between olanzapine and aripiprazole for schizophrenia

机译：奥氮平与阿立哌唑治疗精神分裂症的疗效和安全性的间接比较分析

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Aims Indirect comparison (IC) and direct comparison (DC) between aripiprazole and olanzapine for schizophrenia were conducted to compare their efficacy and safety. The objective was to determine the usability of IC and consistency of results delivered by the two comparisons. Factors that might influence the inconsistency of results were also investigated. Methods ICs and DCs were conducted using the change from baseline of the Positive and Negative Syndrome Scale (PANSS) total score as an efficacy endpoint and the dropout rate was selected as a safety endpoint. Placebo and risperidone were used as common comparators for ICs.Results A literature search identified 20 articles. The efficacy analysis gave results on the mean difference in PANSS change (95% CI) of 5.72 (10.22, 1.22) in ICs using placebo as a common comparator and 7.41 (15.96, 1.14) in DCs. When using risperidone as a common comparator, it was 9.15 (?20.12, 1.82). In rate ratio analysis of the all cause dropout rate, the IC result was 1.17 (0.83, 1.65) using placebo as a common comparator and 1.56 (0.57, 4.26) using risperidone as a common comparator. Both analyses gave consistent results between ICs and DCs. A slightly lower estimated value was observed in ICs using placebo. Conclusions This study demonstrated that ICs between olanzapine and aripiprazole can deliver results consistent with those of DCs. It is also suggested that the selection of a common comparator is important when control group bias is suspected in the data set.
机译：目的进行阿立哌唑和奥氮平对精神分裂症的间接比较（IC）和直接比较（DC），以比较它们的疗效和安全性。目的是确定IC的可用性和两次比较得出的结果的一致性。还研究了可能影响结果不一致的因素。方法采用阳性和阴性综合症状量表（PANSS）总评分的基线变化作为疗效终点，并选择辍学率作为安全终点，进行IC和DC。安慰剂和利培酮用作IC的常见比较剂。结果文献检索发现20篇文章。功效分析得出的结果是，使用安慰剂作为常见比较剂的IC中PANSS变化（95％CI）的平均差异为5.72（10.22，1.22），而在DC中为7.41（15.96，1.14）。当使用利培酮作为普通的比较剂时，为9.15（〜20.12，1.82）。在所有原因退出率的比率分析中，使用安慰剂作为通用比较器的IC结果为1.17（0.83，1.65），使用利培酮作为通用比较器的IC结果为1.56（0.57，4.26）。两种分析都给出了IC和DC之间的一致结果。使用安慰剂的IC中观察到的估计值略低。结论这项研究表明，奥氮平和阿立哌唑之间的IC可以提供与DC一致的结果。还建议当怀疑数据集中有对照组偏倚时，选择通用比较器很重要。

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