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首页> 外文期刊>British Journal of Dermatology >Subcellular activation site of caspase-3 in apoptotic keratinocytes observed in lichenoid tissue reaction.
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Subcellular activation site of caspase-3 in apoptotic keratinocytes observed in lichenoid tissue reaction.

机译：在类苔质组织反应中观察到凋亡性角质形成细胞中caspase-3的亚细胞激活位点。

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摘要

Sir, The lichenoid tissue reaction (LTR) is the most common form of a T-cell-mediated disease state. Many clinically heterogeneous skin diseases, ranging from lupus erythematosus to fixed drug eruption, have various elements of LTR. Histologically, it is characterized by dense interface lymphocyte infiltration and the formation of colloidal bodies. These ovoid eosinophilic bodies are often surrounded by 'satellite' lymphocytes. The presence of dyskeratotickeratinocytes and satellite-cell necrosis are common features of LTR. This apoptotic process is mediated by CD8+ cytotoxic T lymphocytes (CTCL) and natural killer (NK) cells. The two main distinct pathways, the perform/granzymeB pathway and the CD-95/CD-95L pathway, arethought to be involved in this apoptotic process in the LTR. Thus, apoptosis is thought to be the mechanism of cell death in the LTR.Apoptosis is a physiologically important process leading to a highly regulated, programmed form of cell death. Programmed cell death is a normal part of growth and development and oncogenesis. This process is controlled by numerous proteins, including a family of cysteine aspaxtic acid proteases known as caspases. Caspases regulate apoptosis by cleaving target proteins at specific amnio-acid residues at several steps within a proteolytic cascade.
机译：主席先生，地衣样组织反应（LTR）是T细胞介导的疾病状态的最常见形式。从红斑狼疮到固定的药疹，许多临床上异质的皮肤疾病具有LTR的各种元素。在组织学上，其特征是致密的界面淋巴细胞浸润和胶体形成。这些卵圆形的嗜酸性体通常被“卫星”淋巴细胞包围。角质化角化细胞和卫星细胞坏死的存在是LTR的常见特征。这种凋亡过程是由CD8 +细胞毒性T淋巴细胞（CTCL）和自然杀伤（NK）细胞介导的。 LTR的这一凋亡过程被认为是两个主要不同的途径，即perform / granzymeB途径和CD-95 / CD-95L途径。因此，凋亡被认为是LTR中细胞死亡的机制。凋亡是生理上重要的过程，导致高度调控的程序性细胞死亡形式。程序性细胞死亡是生长发育和肿瘤发生的正常部分。该过程由许多蛋白质控制，包括一个称为胱天蛋白酶的半胱氨酸天冬氨酸蛋白酶家族。胱天蛋白酶通过在蛋白水解级联反应的多个步骤中在特定的氨基酸残基处裂解靶蛋白来调节细胞凋亡。

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