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首页> 外文期刊>British Journal of Dermatology >An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer.
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An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer.

机译：使用可穿戴式低辐射有机发光二极管光源进行非卧床光动力疗法的开放式先导研究，用于治疗非黑色素瘤皮肤癌。

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BACKGROUND: Photodynamic therapy (PDT) is a popular treatment for nonmelanoma skin cancer with clearance rates of between 70% and 100%. Although reported to have a superior cosmetic outcome, the inconvenience of hospital visits and discomfort during therapy are considered drawbacks. OBJECTIVES: To present an open pilot study of a low-irradiance, potentially disposable, lightweight, organic light-emitting diode (OLED), which is an area-emitting light source (2 cm diameter), suitable for ambulatory PDT. METHODS: Twelve patients with Bowen's disease (eight) and superficial basal cell carcinoma (four) < 2 cm in diameter were recruited into the study following histological confirmation of the diagnosis. Two treatments (45-60 J cm(-2) red light, 550-750 nm, peak 620 nm, irradiance 5 mW cm(-2)) were administered 1 month apart following application of aminolaevulinic acid for 4 h. RESULTS: At the 12-month follow-up, seven of the 12 patients remained clear, with four of the nonresponders demonstrating peripheral margin failure. Patients were scored for pain during and immediately after treatment using the numerical rating scale (NRS; 1-10). All 12 subjects scored pain as < 2 using the NRS (median score 1). In contrast, a similar cohort of 50 consecutive patients from our routine PDT clinic (Aktilite inorganic LED source; 75 J cm(-2), irradiance 80 mW cm(-2)) scored a median of 6 on the NRS. CONCLUSIONS: Pain and inconvenience are practical barriers to the use of conventional PDT. This pilot study suggests that OLED-PDT is less painful than conventional PDT with the added advantage of being lightweight, and therefore has the potential for more convenient 'home PDT'. These results need to be validated in larger studies.
机译：背景：光动力疗法（PDT）是非黑素瘤皮肤癌的一种流行疗法，其清除率在70％至100％之间。尽管据报道具有良好的美容效果，但治疗过程中医院就诊的不便和不适被认为是缺点。目的：提出一项低辐射，潜在可抛弃，轻巧的有机发光二极管（OLED）的开放式先导研究，该发光二极管是面积发光的光源（直径2厘米），适用于动态PDT。方法：经组织学确认诊断后，招募了12例鲍恩氏病（8例）和浅表基底细胞癌（4例），直径<2 cm。施用氨基乳清酸4小时后，相隔1个月进行两次治疗（45-60 J cm（-2）红光，550-750 nm，峰值620 nm，辐照度5 mW cm（-2））。结果：在12个月的随访中，12例患者中有7例保持清晰，其中4例无反应者表现为周围边缘衰竭。使用数字评分量表（NRS; 1-10）对患者在治疗期间和治疗后的疼痛进行评分。使用NRS，所有12位受试者的疼痛评分均<2（中位数为1）。相比之下，来自我们常规PDT诊所的50名连续患者的类似队列（Aktilite无机LED光源; 75 J cm（-2），辐照度80 mW cm（-2））在NRS上的中位数为6。结论：疼痛和不便是常规PDT使用的实际障碍。这项初步研究表明，OLED-PDT较传统的PDT减轻痛苦，并且具有重量轻的额外优势，因此有可能提供更方便的“家用PDT”。这些结果需要在更大的研究中得到验证。

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