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首页> 外文期刊>Gut: Journal of the British Society of Gastroenterology >New perspectives in the therapy of chronic hepatitis B
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New perspectives in the therapy of chronic hepatitis B

机译：慢性乙型肝炎治疗的新观点

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Since approval of the first nucleos(t)ide analogue (NUC) in 1998, remarkable advances have been made in antiviral treatment of chronic hepatitis B virus (HBV) infection. Both interferon-based therapy and treatment with NUCs have evolved to the stage that pegylated interferon (Peg-IFN) has replaced conventional IFN, and entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have become the first-line oral treatments.1^3 As the therapeutic outcomes are still far from satisfactory, many attempts have been made to optimise antiviral therapy of chronic HBV infection. Along with the evolution of drug therapy, quantitation of hepatitis B surface antigen (HBsAg) has gained popularity as a clinically useful seromarker for assessing the natural course and response to therapy of chronic HBV infection. In addition, the discovery of IL28B polymorphism, which has shed new light on the treatment of hepatic C virus (HCV) infection, has been applied in the study of the response of patients with HBV to IFN regimens. These recent developments are reviewed in this article, focusing on the following topics: IL28B and response to IFN or Peg-IFN therapy; response-guided therapy of Peg-IFN treatment; ETV and TDF in field practice naive patients.
机译：自从1998年第一个核苷酸类似物（NUC）获批以来，在抗病毒治疗慢性乙型肝炎病毒（HBV）方面取得了显着进展。基于干扰素的治疗和使用NUC的治疗均已发展到聚乙二醇化干扰素（Peg-IFN）取代传统IFN的阶段，恩替卡韦（ETV）和替诺福韦二富马酸富马酸（TDF）已成为一线口服治疗。1^ 3由于治疗效果仍然不能令人满意，因此已进行了许多尝试来优化慢性HBV感染的抗病毒治疗。随着药物疗法的发展，对乙型肝炎表面抗原（HBsAg）的定量已作为一种临床上有用的血清标记物而得到普及，用于评估慢性病程和对慢性HBV感染的治疗反应。此外，IL28B基因多态性的发现为治疗C型肝炎病毒（HCV）感染提供了新的亮点，已被用于研究HBV患者对IFN方案的反应。本文对这些最新进展进行了综述，重点关注以下主题：IL28B和对IFN或Peg-IFN治疗的反应; Peg-IFN治疗的反应指导治疗;未经培训的ETV和TDF用于未成年人的现场实践。

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