Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

Antony Cougnoux; Guillaume Dalmasso; Ruben Martinez; Emmanuel Buc; Julien Delmas; Lucie Gibold; Pierre Sauvanet; Claude Darcha

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Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

机译：细菌基因毒素大肠菌素通过诱导衰老相关的分泌表型促进结肠肿瘤的生长

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Background Escherichia coli strains harbouring the pks island (pks+ E. coli) are often seen in human colorectal tumours and have a carcinogenic effect independent of inflammation in an AOM/IL-10~(-/-) (azoxymethane/ interleukin) mouse model. Objective To investigate the mechanism sustaining pks+ E. coli-induced carcinogenesis. Method Underlying cell processes were investigated in vitro and in vivo (xenograft model) using intestinal epithelial cells infected by pks+ E. coli or by an isogenic mutant defective for pks (pks- E. coli). The results were supported by data obtained from an AOM/DSS (azoxymethane/dextran sodium sulphate) colon cancer mouse model and from human colon cancer biopsy specimens colonised by pks+ E. coli or pks- E. coli.

机译：背景技术带有pks岛（pks +大肠杆菌）的大肠杆菌菌株通常在人大肠肿瘤中发现，并且在AOM / IL-10〜（-/-）（乙氧基甲烷/白介素）小鼠模型中具有独立于炎症的致癌作用。目的探讨维持pks +大肠杆菌致癌作用的机制。方法使用感染了pks +大肠杆菌或pks缺陷的同基因突变体（pks- E. coli）感染的肠上皮细胞，在体外和体内研究了基本的细胞过程（异种移植模型）。该结果得到了从AOM / DSS（乙氧基甲烷/右旋糖酐硫酸钠）结肠癌小鼠模型以及由pks +大肠杆菌或pks-E。coli克隆的人结肠癌活检标本获得的数据的支持。

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《Gut: Journal of the British Society of Gastroenterology》 |2014年第12期|共11页
作者
Antony Cougnoux; Guillaume Dalmasso; Ruben Martinez; Emmanuel Buc; Julien Delmas; Lucie Gibold; Pierre Sauvanet; Claude Darcha;
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正文语种 eng
中图分类消化系及腹部疾病;
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1. Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype [J] . Antony Cougnoux, Guillaume Dalmasso, Ruben Martinez, Gut: Journal of the British Society of Gastroenterology . 2014,第12期

机译：细菌基因毒素大肠菌素通过诱导衰老相关的分泌表型促进结肠肿瘤的生长
2. Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells [J] . Anna Strzeszewska, Olga Alster, Gra?yna Mosieniak, Cell death & disease. . 2018,第2期

机译：深入了解PIKK家族成员和NF-кB在DNA损伤诱导的结肠癌细胞衰老及与衰老相关的分泌表型中的作用
3. Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells [J] . Anna Strzeszewska, Olga Alster, Gra?yna Mosieniak, Cell death & disease. . 2018,第2期

机译：深入了解PIKK家族成员和NF-кB在DNA损伤诱导的结肠癌细胞衰老及与衰老相关的分泌表型中的作用
4. Combinatorial, microparticle-based delivery of immune modulators reprograms dendritic cell phenotype and promotes remission of collagen-induced arthritis in mice [C] . Riley Allen, Shawn Chizari, Luke McKibbin, Society for Biomaterials annual meeting and exposition . 2019

机译：免疫调节剂的组合，基于微粒的递送重新编程树突状细胞表型，并促进小鼠胶原诱导的关节炎的缓解
5. Redox-Dependent Calcium-Mediated Signaling Networks that Control the Senescence-Associated Secretory Phenotype. [D] . Chandrasekaran, Akshaya. 2017

机译：依赖氧化还原的钙介导的信号网络，控制衰老相关的分泌表型。
6. The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment [O] . Guillaume Dalmasso, Antony Cougnoux, Julien Delmas, 2014

机译：细菌遗传毒素大肠菌素通过修饰肿瘤微环境促进结肠肿瘤生长
7. Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells [O] . Anna Strzeszewska, Olga Alster, Grażyna Mosieniak, 2018

机译：洞察帕克克家族成员和NF-кB在霉菌诱导的衰老和衰老相关分泌表型的结肠癌细胞的作用

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

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