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首页> 外文期刊>Gut: Journal of the British Society of Gastroenterology >Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial
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Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial

机译：诱导后血清英夫利昔单抗谷水平和C反应蛋白水平降低与对英夫利昔单抗的持久持续反应有关：ACCENT I试验的回顾性分析

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Background Serum infliximab trough levels correlate with efficacy; dose escalation is often beneficial in patients with Crohn's disease who stop responding to infliximab treatment. Objective To carry out a post hoc analysis of A Crohn's Disease Clinical Trial Evaluating Infliximab in a New Long-term Treatment Regimen I (ACCENT I) to evaluate the association between serum infliximab trough levels and C-reactive protein (CRP) after 14 weeks of induction treatment with durable sustained long-term response (Crohn's Disease Activity Index decrease >70 points and reduction >25% from baseline). Design ACCENT I was a multicentre, randomised, placebo-controlled study. Week 14 trough levels and CRP percentage decrease from baseline to week 14 were compared between patients with and without durable sustained response through week 54. Sensitivity and specificity were determined to predict durable sustained response. Receiver operating characteristic (ROC) curves identified optimal cut-off points; logistic regression determined ORs.
机译：背景血清英夫利昔单抗谷水平与疗效相关。克罗恩氏病患者对英夫利昔单抗治疗无效，通常剂量增加通常是有益的。目的对一项新的长期治疗方案I（ACCENT I）中的克罗恩病临床试验评估英夫利昔单抗进行事后分析，以评估14周后英夫利昔单抗谷水平与C反应蛋白（CRP）的相关性。诱导疗法具有持久的持续长期响应（克罗恩氏病活动指数比基线降低> 70点，且降低> 25％）。设计ACCENT I是一项多中心，随机，安慰剂对照的研究。比较了有无持续持续反应的患者至第54周从基线到第14周的第14周谷值水平和CRP百分比降低。确定敏感性和特异性以预测持续持续反应。接收器工作特性（ROC）曲线确定了最佳截止点; Logistic回归确定OR。

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