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首页> 外文期刊>Gut: Journal of the British Society of Gastroenterology >Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease
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Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease

机译：长期摄入饮食脂肪和患溃疡性结肠炎和克罗恩病的风险

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Introduction: Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited and conflicting. Methods: We conducted a prospective study of women enrolled in the Nurses' Health Study cohorts. Diet was prospectively ascertained every 4 years using a validated semi-quantitative food frequency questionnaire. Self-reported CD and UC were confirmed through medical record review. We examined the effect of energy-adjusted cumulative average total fat intake and specific types of fat and fatty acids on the risk of CD and UC using Cox proportional hazards models adjusting for potential confounders. Results: Among 170 805 women, we confirmed 269 incident cases of CD (incidence 8/100 000 person-years) and 338 incident cases of UC (incidence 10/100 000 person-years) over 26 years and 3 317 338 person-years of follow-up. Cumulative energy-adjusted intake of total fat, saturated fats, unsaturated fats, n-6 and n-3 polyunsaturated fatty acids (PUFAs) were not associated with risk of CD or UC. However, greater intake of long-chain n-3 PUFAs was associated with a trend towards lower risk of UC (HR 0.72, 95% CI 0.51 to 1.01). In contrast, high long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of UC (HR 1.34, 95% CI 0.94 to 1.92). Conclusions: A high intake of dietary long-chain n-3 PUFAs may be associated with a reduced risk of UC. In contrast, high intake of trans-unsaturated fats may be associated with an increased risk of UC.
机译：简介：膳食脂肪会影响肠道炎症并调节粘膜免疫力。关于饮食脂肪与克罗恩病（CD）和溃疡性结肠炎（UC）风险之间的关联的数据有限且相互矛盾。方法：我们对参加“护士健康研究”队列的妇女进行了一项前瞻性研究。使用经过验证的半定量食物频率调查表，每4年对饮食进行一次前瞻性检查。自我报告的CD和UC通过病历审查得到确认。我们使用针对潜在混杂因素进行调整的Cox比例风险模型，研究了能量调整的累积平均总脂肪摄入量以及特定类型的脂肪和脂肪酸对CD和UC风险的影响。结果：在170805名女性中，我们确诊了269例CD发病（发病率8/100 000人年）和338例UC发病病例（发病率10/100 000人年），持续了26年和3 317 338人年。的后续行动。总脂肪，饱和脂肪，不饱和脂肪，n-6和n-3多不饱和脂肪酸（PUFA）的累积能量调整摄入量与CD或UC风险无关。但是，长链n-3 PUFA的摄入量增加与UC风险降低的趋势相关（HR 0.72，95％CI 0.51至1.01）。相反，长期大量摄入反式不饱和脂肪酸与UC发生率增加的趋势有关（HR 1.34，95％CI 0.94至1.92）。结论：饮食中长链n-3 PUFA的高摄入量可能与UC风险降低有关。相反，反式不饱和脂肪的大量摄入可能与UC风险增加有关。

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