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首页> 外文期刊>Familial cancer >Mullerian intra-abdominal carcinomatosis in hereditary breast ovarian cancer syndrome: implications for risk-reducing surgery
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Mullerian intra-abdominal carcinomatosis in hereditary breast ovarian cancer syndrome: implications for risk-reducing surgery

机译：遗传性乳腺癌卵巢癌综合征中的苗勒氏腹腔内癌变：对降低风险的手术的意义

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摘要

More than 40 years ago Lynch et al. described several multigenerational breast cancer family pedigrees which demonstrated autosomal dominant inheritance of a trait(s) that increased risks for both breast and ovarian cancers. Mutation carriers in at least 90 % of these hereditary breast ovarian cancer (HBOC) syndrome families have been linked to cancer-associated mutations in the genes BRCA1 and BRCA2. This review focuses on the contributions of Lynch, colleagues and collaborators and pertinent literature, toward defining the HBOC syndrome, the cancer risks that the inherited adverse mutations convey, the gynecologic tissues and organs from which the malignancy may arise to disseminate throughout the pelvic and abdominal organs and peritoneum and how this information can be used to reduce the risk and morbidities of intra-abdominal carcinomatosis in effected individuals.
机译：40年前，Lynch等人。描述了几个多代乳腺癌家族谱系，这些家族谱系表明常染色体显性遗传性状增加了乳腺癌和卵巢癌风险的性状。这些遗传性乳腺癌（HBOC）综合征家族中至少有90％的突变携带者与BRCA1和BRCA2基因中与癌症相关的突变相关。这篇综述着重于Lynch，同事和合作者以及相关文献的贡献，以定义HBOC综合征，遗传的不良突变所传达的癌症风险，可能引起恶性肿瘤扩散到整个骨盆和腹部的妇科组织和器官器官和腹膜以及如何使用这些信息来降低患病者腹腔内癌变的风险和发病率。

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