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首页> 外文期刊>Growth Factors >A system for quantifying the patterning of the lymphatic vasculature.
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A system for quantifying the patterning of the lymphatic vasculature.

机译：用于量化淋巴管系统构图的系统。

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摘要

The lymphatic vasculature is critical for immunity and interstitial fluid homeostasis, playing important roles in diseases such as lymphedema and metastatic cancer. Animal models have been generated to explore the role of lymphatics and lymphangiogenic growth factors in such diseases, and to study lymphatic development. However, analysis of lymphatic vessels has primary been restricted to counting lymphatics in two-dimensional tissue slices, due to a lack of more sophisticated methodologies. In order to accurately examine lymphatic dysfunction in these models, and analyse the effects of lymphangiogenic growth factors on the lymphatic vasculature, it is essential to quantify the morphology and patterning of the distinct lymphatic vessels types in three-dimensional tissues. Here, we describe a method for performing such analyses, integrating user-operated image-analysis software with an approach that considers important morphological, anatomical and patterning features of the distinct lymphatic vessel subtypes. This efficient, reproducible technique is validated by analysing healthy and pathological tissues.
机译：淋巴管对免疫力和间质液稳态至关重要，在淋巴水肿和转移性癌症等疾病中起重要作用。已经建立了动物模型以探索淋巴管和淋巴管生成生长因子在此类疾病中的作用，并研究淋巴管的发育。然而，由于缺乏更复杂的方法，对淋巴管的分析主要局限于对二维组织切片中的淋巴管进行计数。为了准确检查这些模型中的淋巴功能障碍，并分析淋巴管生成因子对淋巴管系统的影响，对三维组织中不同淋巴管类型的形态和模式进行定量分析至关重要。在这里，我们描述了一种执行此类分析的方法，将用户操作的图像分析软件与一种考虑了不同淋巴管亚型的重要形态，解剖学和图案特征的方法相结合。通过分析健康和病理组织验证了这种有效，可重复的技术。

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