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首页> 外文期刊>Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society >Instability of IGF-IGFBP complex as a cause of the different performance of serum and EDTA-plasma after storage: EDTA-plasma is preferable for evaluating bioactive IGF especially in the mouse
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Instability of IGF-IGFBP complex as a cause of the different performance of serum and EDTA-plasma after storage: EDTA-plasma is preferable for evaluating bioactive IGF especially in the mouse

机译：IGF-IGFBP复合物的不稳定性是储存后血清和EDTA血浆性能不同的原因：EDTA血浆特别适用于评估小鼠中的生物活性IGF，尤其是小鼠

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摘要

Objective: The insulin-like growth factor (IGF) signaling pathway is recognized as a potential target for treating several cancers, and strategies targeting the IGF type 1 receptor (IGF-1R) have been evaluated in many clinical trials. These suggested that the pretreatment level of circulating free IGF gives an estimate of IGF bioactivity and might be a predictive biomarker of the response to anti-IGF-1R antibodies. However, there is no defined protocol for measuring free and bioactive IGF concentrations, partly because the measurement procedures, including sample collection and handling, have not been standardized. We investigated the effects of sample collection methods and storage conditions on bioactive IGF measurement using a modified kinase receptor activation (KIRA) assay in human and mouse samples.
机译：目的：胰岛素样生长因子（IGF）信号通路被认为是治疗多种癌症的潜在靶标，并且在许多临床试验中已经评估了靶向IGF 1型受体（IGF-1R）的策略。这些提示循环游离IGF的预处理水平估计了IGF的生物活性，并且可能是对抗IGF-1R抗体反应的预测性生物标志。但是，目前尚无用于测量游离和具有生物活性的IGF浓度的明确协议，部分原因是测量程序（包括样品收集和处理）尚未标准化。我们调查了人类和小鼠样品中使用改进的激酶受体激活（KIRA）测定的生物活性IGF测量中样品收集方法和存储条件的影响。

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